The fountain of youth has always been a myth for mankind. Aging is a physiologic state in
which a progressive decline of organ functions is accompanied with the development of age …

Reactive oxygen species, when released under controlled conditions and limited amounts,
contribute to cellular proliferation, senescence, and survival by acting as signaling …

Non-alcoholic fatty liver disease (NAFLD) is the major public health challenge for
hepatologists in the twenty-first century. NAFLD comprises a histological spectrum ranging …

Objective Ovarian senescence affects many tissues and produces a variety of symptoms and
signs. We hypothesized that estrogens may also influence circulating redox balance by …

Background: The mechanisms of progression from fatty liver to steatohepatitis and cirrhosis
are not well elucidated. Mitochondrial dysfunction represents a key factor in the progression …

A practical nurse rostering problem, which arises at a ward of an Italian hospital, is
considered. The nurse rostering problem is a typical employee timetabling problem, where …

Deficits in glutamate neurotransmission and mitochondrial functions were detected in the
frontal cortex (FC) and hippopcampus (HIPP) of aged 3× Tg-Alzheimer's disease (AD) mice …

Background Novel direct-acting antivirals (DAAs) have completely changed the panorama of
hepatitis C due to their high efficacy and optimal safety profile. Unfortunately, an …

There is growing evidence that mitochondrial dysfunction, and more specifically fatty acid β-
oxidation impairment, is involved in the pathophysiology of non-alcoholic steatohepatitis …

Safety of healthcare workers in hospitals is a major concern during the COVID-19 pandemic.
Being exposed for several working hours per day to infected patients, nurses dealing with …