Intestinal microbiota contributes to individual susceptibility to alcoholic liver disease

…, F Cailleux, AM González-Castro, S Rabot, F Gaudin… - Gut, 2016 - gut.bmj.com
Objective There is substantial inter-individual diversity in the susceptibility of alcoholics to
liver injury. Alterations of intestinal microbiota (IM) have been reported in alcoholic liver …

Fecal microbiota manipulation prevents dysbiosis and alcohol-induced liver injury in mice

…, D Rainteau, L Humbert, C Hugot, F Gaudin… - Journal of …, 2017 - Elsevier
Background & Aims Alcoholic liver disease (ALD) is a leading cause of liver failure and
mortality. In humans, severe alcoholic hepatitis is associated with key changes to intestinal …

Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis

…, V Godie, F Cailleux, ML Renoud, F Gaudin… - Journal of …, 2012 - Elsevier
BACKGROUND & AIMS: Non-alcoholic steatohepatitis (NASH) is characterized by steatosis
associated with liver inflammation. Steatosis causes recruitment of lymphocytes into the liver …

Squalene-based multidrug nanoparticles for improved mitigation of uncontrolled inflammation in rodents

…, A Peramo, A Gendron, J Mougin, F Gaudin… - Science …, 2020 - science.org
Uncontrolled inflammatory processes are at the root of numerous pathologies. Most recently,
studies on confirmed COVID-19 cases have suggested that mortality might be due to virally …

[HTML][HTML] Potential role of estrogen receptor beta as a tumor suppressor of epithelial ovarian cancer

C Bossard, M Busson, D Vindrieux, F Gaudin… - 2012 - journals.plos.org
Ovarian cancer is the gynecological cancer exhibiting the highest morbidity and
improvement of treatments is still required. Previous studies have shown that Estrogen …

Pulsative flushing as a strategy to prevent bacterial colonization of vascular access devices

A Ferroni, F Gaudin, G Guiffant, P Flaud… - Medical Devices …, 2014 - Taylor & Francis
Central venous device infections are associated with increased physical and psychological
morbidity, mortality, length of stay, and costs. The aim of this study was to prove the efficacy …

Cardiac overexpression of PDE4B blunts β-adrenergic response and maladaptive remodeling in heart failure

…, M Lindner, K Bouadjel, M Dessillons, F Gaudin… - Circulation, 2020 - Am Heart Assoc
Background: The cyclic AMP (adenosine monophosphate; cAMP)-hydrolyzing protein
PDE4B (phosphodiesterase 4B) is a key negative regulator of cardiac β-adrenergic receptor …

Dexamethasone palmitate nanoparticles: An efficient treatment for rheumatoid arthritis

M Lorscheider, N Tsapis, F Gaudin, I Stolfa… - Journal of controlled …, 2019 - Elsevier
Rheumatoid arthritis (RA) is a prevalent autoimmune disease characterized by joint
inflammation, bone and cartilage erosion. The use of glucocorticoids in the treatment of RA …

[HTML][HTML] Biofilm Structures in a Mono-Associated Mouse Model of Clostridium difficile Infection

AP Soavelomandroso, F Gaudin, S Hoys… - Frontiers in …, 2017 - frontiersin.org
Clostridium difficile infection (CDI) is a major healthcare-associated disease with high
recurrence rates. Host colonization is critical for the infectious process, both in first episodes …

Evaluation of a new packing material for H2S removed by biofiltration

E Dumont, Y Andres, P Le Cloirec, F Gaudin - Biochemical Engineering …, 2008 - Elsevier
This study aims to evaluate the feasibility of using a new packing material (UP20) in treating
H2S. Three identical laboratory-scale biofilters, filled with, respectively, UP20 alone, pine …