Narcolepsy—clinical spectrum, aetiopathophysiology, diagnosis and treatment

…, S Gay, U Kallweit, R Khatami, F Koning… - Nature Reviews …, 2019 - nature.com
Narcolepsy is a rare brain disorder that reflects a selective loss or dysfunction of orexin (also
known as hypocretin) neurons of the lateral hypothalamus. Narcolepsy type 1 (NT1) is …

[HTML][HTML] Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules

…, SW Qiao, RP Anderson, C Gianfrani, F Koning - Immunogenetics, 2012 - Springer
Celiac disease is caused by an abnormal intestinal T-cell response to gluten proteins of
wheat, barley and rye. Over the last few years, a number of gluten T-cell epitopes restricted …

[HTML][HTML] Celiac disease: how complicated can it get?

JML Tjon, J van Bergen, F Koning - Immunogenetics, 2010 - Springer
In the small intestine of celiac disease patients, dietary wheat gluten and similar proteins in
barley and rye trigger an inflammatory response. While strict adherence to a gluten-free diet …

The intestinal T cell response to α-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase

…, W Vader, YMC Kooy, KEA Lundin, F Koning… - The Journal of …, 2000 - rupress.org
The great majority of patients that are intolerant of wheat gluten protein due to celiac disease
(CD) are human histocompatibility leukocyte antigen (HLA)-DQ2+, and the remaining few …

Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study

…, HW Verspaget, EMC Kooy-Winkelaar, F Koning… - Gut, 2010 - gut.bmj.com
Background and aim Mesenchymal stromal cells (MSCs) are pluripotent cells that have
immunosuppressive effects both in vitro and in experimental colitis. Promising results of …

[HTML][HTML] γδ T cells are effectors of immunotherapy in cancers with HLA class I defects

…, TN Schumacher, LFA Wessels, F Koning… - Nature, 2023 - nature.com
DNA mismatch repair-deficient (MMR-d) cancers present an abundance of neoantigens that
is thought to explain their exceptional responsiveness to immune checkpoint blockade …

Cutting edge: selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity

…, L Mearin, G Papadopoulos, F Koning - The Journal of …, 1998 - journals.aai.org
Celiac disease (CD) is caused by gluten ingestion in susceptible individuals. Tissue
transglutaminase (tTG)-specific Abs are characteristic of CD, and increased tTG activity has …

Identification of a graft versus host disease-associated human minor histocompatibility antigen

…, NE Sherman, E Blokland, E Huczko, F Koning… - Science, 1995 - science.org
Minor histocompatibility antigen disparities between human leukocyte antigen (HLA)-
matched bone marrow donors and recipients are a major risk factor for graft versus host …

[HTML][HTML] Randomized feeding intervention in infants at high risk for celiac disease

…, A Ivarsson, T Koltai, F Koning… - … England Journal of …, 2014 - Mass Medical Soc
Background A window of opportunity has been suggested for reducing the risk of celiac
disease by introducing gluten to infants at 4 to 6 months of age. Methods We performed a …

The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides

…, S Peña, L Mearin, JW Drijfhout, F Koning - Gastroenterology, 2002 - Elsevier
Background & Aims: Gluten (GLU)-specific T-cell responses in HLA-DQ2 positive adult
celiac disease (CD) patients are directed to an immunodominant α-gliadin (GLIA) peptide …