SUMMARY ETEC is an underrecognized but extremely important cause of diarrhea in the
developing world where there is inadequate clean water and poor sanitation. It is the most …

Vibrio is a genus of ubiquitous bacteria found in a wide variety of aquatic and marine
habitats; of the> 100 described Vibrio spp.,~ 12 cause infections in humans. Vibrio cholerae …

Background Killed whole-cell oral cholera vaccines (kOCVs) are becoming a standard
cholera control and prevention tool. However, vaccine efficacy and direct effectiveness …

Summary Background Shigella and enterotoxigenic Escherichia coli (ETEC) are bacterial
pathogens that are frequently associated with diarrhoeal disease, and are a significant …

The factors that enhance the transmission of pathogens during epidemic spread are ill
defined. Water-borne spread of the diarrhoeal disease cholera occurs rapidly in nature …

Background Antibiotic resistance is rising in important bacterial pathogens. Phage therapy
(PT), the use of bacterial viruses infecting the pathogen in a species-specific way, is a …

Background—Hypertensive target organ damage, especially cardiac hypertrophy with heart
failure and arrhythmia, is a major source of morbidity and mortality. Angiotensin II, a major …

The renin-angiotensin system (RAS) participates in preeclampsia; however, the relative
contributions from the circulating RAS and the tissue-based, uteroplacental RAS are …

OBJECTIVE: Oral vaccine efficacy is low in less-developed countries, perhaps due to
intestinal dysbiosis. This study determined if stool microbiota composition predicted infant …

Serotonin synthesis in mammals is initiated by 2 distinct tryptophan hydroxylases (TPH),
TPH1 and TPH2. By genetically ablating TPH2, we created mice (Tph2−/−) that lack …