Background The current COVID‐19 pandemic, caused by SARS‐CoV‐2, has emerged as a
public health emergency. All nations are seriously challenged as the virus spreads rapidly …

Abstract Juvenile Polyposis Syndrome is an uncommon hamartomatous disorder with
significant gastrointestinal malignant potential. Mutations in SMAD4 and BMPR1A …

Background Studies showing that drugs that inhibit cyclooxygenase-2 (COX-2) reduce the
number of colorectal adenomas in animals and patients with familial adenomatous …

Background Observational studies report reduced colorectal cancer in regular aspirin
consumers. Randomised controlled trials have shown reduced risk of adenomas but none …

Colorectal cancer (CRC), one of the most common cancers, is a major public health issue
globally, especially in Westernized countries. Up to 35% of CRCs are thought to be due to …

Summary Background Most patients with Crohn's disease need an intestinal resection, but a
majority will subsequently experience disease recurrence and require further surgery. This …

Background Most patients with path_MMR gene variants (Lynch syndrome (LS)) now
survive both their first and subsequent cancers, resulting in a growing number of older …

Objective Estimates of cancer risk and the effects of surveillance in Lynch syndrome have
been subject to bias, partly through reliance on retrospective studies. We sought to establish …

The clinical classification of hereditary sequence variants identified in disease-related genes
directly affects clinical management of patients and their relatives. The International Society …

Purpose Pathogenic variants affecting MLH1, MSH2, MSH6, and PMS2 cause Lynch
syndrome and result in different but imprecisely known cancer risks. This study aimed to …