Mutant ATRX: uncovering a new therapeutic target for glioma
S Haase, MB Garcia-Fabiani, S Carney… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: ATRX is a chromatin remodeling protein whose main function is the deposition
of the histone variant H3. 3. ATRX mutations are widely distributed in glioma, and correlate …
of the histone variant H3. 3. ATRX mutations are widely distributed in glioma, and correlate …
Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer
Y Zhang, A Velez-Delgado, E Mathew, D Li… - Gut, 2017 - gut.bmj.com
Background Pancreatic cancer is characterised by the accumulation of a fibro-inflammatory
stroma. Within this stromal reaction, myeloid cells are a predominant population. Distinct …
stroma. Within this stromal reaction, myeloid cells are a predominant population. Distinct …
IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response
FJ Núñez, FM Mendez, P Kadiyala… - Science translational …, 2019 - science.org
Patients with glioma whose tumors carry a mutation in isocitrate dehydrogenase 1
(IDH1R132H) are younger at diagnosis and live longer. IDH1 mutations co-occur with other …
(IDH1R132H) are younger at diagnosis and live longer. IDH1 mutations co-occur with other …
Epigenetic reprogramming and chromatin accessibility in pediatric diffuse intrinsic pontine gliomas: A neural developmental disease
FM Mendez, FJ Núñez, MB Garcia-Fabiani… - Neuro …, 2020 - academic.oup.com
Diffuse intrinsic pontine glioma (DIPG) is a rare but deadly pediatric brainstem tumor. To
date, there is no effective therapy for DIPG. Transcriptomic analyses have revealed DIPGs …
date, there is no effective therapy for DIPG. Transcriptomic analyses have revealed DIPGs …
[HTML][HTML] Immune-stimulatory (TK/Flt3L) gene therapy opens the door to a promising new treatment strategy against brainstem gliomas
Diffuse intrinsic pontine glioma (DIPG) is a rare brainstem tumor which carries a dismal
prognosis. To date. there are no effective treatments for DIPG. Transcriptomic studies have …
prognosis. To date. there are no effective treatments for DIPG. Transcriptomic studies have …
Evaluation of biomarkers in glioma by immunohistochemistry on paraffin-embedded 3D glioma neurosphere cultures
FJ Núñez, FM Mendez, MB Garcia-Fabiani… - JoVE (Journal of …, 2019 - jove.com
Analysis of protein expression in glioma is relevant for several aspects in the study of its
pathology. Numerous proteins have been described as biomarkers with applications in …
pathology. Numerous proteins have been described as biomarkers with applications in …
[HTML][HTML] Genetically engineered mouse model of brainstem high-grade glioma
FM Nunez, JC Gauss, FM Mendez, S Haase… - STAR protocols, 2020 - Elsevier
Brainstem gliomas are aggressive tumors that are more prevalent in pediatric patients. The
location of these tumors makes them inoperable, and currently there is no effective …
location of these tumors makes them inoperable, and currently there is no effective …
[HTML][HTML] H3. 3-G34R Mutation-Mediated Epigenetic Reprogramming Leads to Enhanced Efficacy of Immune Stimulatory Gene Therapy in Pediatric High-Grade …
Pediatric high-grade gliomas (pHGGs) are diffuse and highly aggressive CNS tumors which
remain incurable, with a 5-year overall survival of less than 20%. Within glioma, mutations in …
remain incurable, with a 5-year overall survival of less than 20%. Within glioma, mutations in …
Native chromatin immunoprecipitation using murine brain tumor neurospheres
FM Mendez, FJ Núñez, RI Zorrilla-Veloz… - JoVE (Journal of …, 2018 - jove.com
Epigenetic modifications may be involved in the development and progression of glioma.
Changes in methylation and acetylation of promoters and regulatory regions of oncogenes …
Changes in methylation and acetylation of promoters and regulatory regions of oncogenes …
Therapeutic efficacy of an immune stimulatory gene therapy strategy in a mouse model of high grade brainstem glioma
FM Mendez, P Kadiyala, FJ Nunez, S Carney, F Nunez… - bioRxiv, 2019 - biorxiv.org
Purpose Diffuse intrinsic pontine glioma (DIPG) bears a dismal prognosis. A genetically
engineered brainstem glioma model harboring the recurrent DIPG mutation, ACVR1-G328V …
engineered brainstem glioma model harboring the recurrent DIPG mutation, ACVR1-G328V …