Antibodies in HIV-1 vaccine development and therapy

F Klein, H Mouquet, P Dosenovic, JF Scheid, L Scharf… - Science, 2013 - science.org
Despite 30 years of study, there is no HIV-1 vaccine and, until recently, there was little hope
for a protective immunization. Renewed optimism in this area of research comes in part from …

[HTML][HTML] Structural insights on the role of antibodies in HIV-1 vaccine and therapy

AP West, L Scharf, JF Scheid, F Klein, PJ Bjorkman… - Cell, 2014 - cell.com
Despite 30 years of effort, there is no effective vaccine for HIV-1. However, antibodies can
prevent HIV-1 infection in humanized mice and macaques when passively transferred. New …

Antibody-mediated neutralization of SARS-CoV-2

H Gruell, K Vanshylla, T Weber, CO Barnes, C Kreer… - Immunity, 2022 - cell.com
Neutralizing antibodies can block infection, clear pathogens, and are essential to provide
long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies …

[HTML][HTML] mRNA booster immunization elicits potent neutralizing serum activity against the SARS-CoV-2 Omicron variant

H Gruell, K Vanshylla, P Tober-Lau, D Hillus… - Nature medicine, 2022 - nature.com
The Omicron variant of SARS-CoV-2 is causing a rapid increase in infections across the
globe. This new variant of concern carries an unusually high number of mutations in key …

[HTML][HTML] Post-COVID syndrome in non-hospitalised patients with COVID-19: a longitudinal prospective cohort study

M Augustin, P Schommers, M Stecher… - The Lancet Regional …, 2021 - thelancet.com
Background While the leading symptoms during coronavirus disease 2019 (COVID-19) are
acute and the majority of patients fully recover, a significant fraction of patients now …

Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding

JF Scheid, H Mouquet, B Ueberheide, R Diskin, F Klein… - Science, 2011 - science.org
Passive transfer of broadly neutralizing HIV antibodies can prevent infection, which suggests
that vaccines that elicit such antibodies would be protective. Thus far, however, few broadly …

Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort …

D Hillus, T Schwarz, P Tober-Lau… - The Lancet …, 2021 - thelancet.com
Background Heterologous vaccine regimens have been widely discussed as a way to
mitigate intermittent supply shortages and to improve immunogenicity and safety of COVID …

COVID‐19 associated pulmonary aspergillosis

P Koehler, OA Cornely, BW Böttiger, F Dusse… - Mycoses, 2020 - Wiley Online Library
Objectives Patients with acute respiratory distress syndrome (ARDS) due to viral infection
are at risk for secondary complications like invasive aspergillosis. Our study evaluates …

Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117

M Caskey, F Klein, JCC Lorenzi, MS Seaman… - Nature, 2015 - nature.com
HIV-1 immunotherapy with a combination of first generation monoclonal antibodies was
largely ineffective in pre-clinical and clinical settings and was therefore abandoned …

Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys

DH Barouch, JB Whitney, B Moldt, F Klein, TY Oliveira… - Nature, 2013 - nature.com
Human immunodeficiency virus type 1 (HIV-1)-specific monoclonal antibodies with
extraordinary potency and breadth have recently been described. In humanized mice …