[HTML][HTML] Testing for ROS1 in non-small cell lung cancer: a review with recommendations

L Bubendorf, R Büttner, F Al-Dayel, M Dietel… - Virchows Archiv, 2016 - Springer
Rearrangements of the ROS1 gene occur in 1–2% of non-small cell lung cancers (NSCLCs).
Crizotinib, a highly effective inhibitor of ROS1 kinase activity, is now FDA-approved for the …

Role of phosphatidylinositol 3′-kinase/AKT pathway in diffuse large B-cell lymphoma survival

S Uddin, AR Hussain, AK Siraj, PS Manogaran… - Blood, 2006 - ashpublications.org
Abstract Phosphatidylinositol 3′-kinase (PI3K) is a key player in cell-growth signaling in a
number of lymphoid malignancies, but its role in diffuse large B-cell lymphoma (DLBCL) has …

Clinicopathological Analysis of Papillary Thyroid Cancer with PIK3CA Alterations in a Middle Eastern Population

J Abubaker, Z Jehan, P Bavi, M Sultana… - The Journal of …, 2008 - academic.oup.com
Context: Genetic aberration in phosphatidylinositol 3-kinase (PI3K)/AKT pathway has been
detected in numerous and diverse human cancers. PIK3CA, which encodes for the catalytic …

[HTML][HTML] Genome-wide expression analysis of Middle Eastern colorectal cancer reveals FOXM1 as a novel target for cancer therapy

S Uddin, M Ahmed, A Hussain, J Abubaker… - The American journal of …, 2011 - Elsevier
To identify genes potentially playing an important role in the progression of colorectal
carcinoma (CRC), we screened global gene expression using cDNA expression array on 41 …

Clinical significance of Blastocystis hominis

SM Qadri, GA al-Okaili, F al-Dayel - Journal of Clinical …, 1989 - Am Soc Microbiol
A total of 19,252 stool specimens from 12,136 patients were examined by direct microscopy
and the ethyl acetate-Formalin concentration method during the last 2 years. All liquid …

[HTML][HTML] Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer

S Uddin, R Bu, M Ahmed, J Abubaker, F Al-Dayel… - Molecular cancer, 2009 - Springer
Background Recent epidemiological studies have suggested that obesity is associated with
ovarian cancer. Obesity hormone leptin and its receptor (Ob-R) contribute to tumor …

HER2, TOP2A, CCND1, EGFR and C-MYC oncogene amplification in colorectal cancer

K Al-Kuraya, H Novotny, P Bavi, AK Siraj… - Journal of clinical …, 2007 - jcp.bmj.com
Aim: Recent studies had suggested substantial molecular differences between tumours from
different ethnic groups. In this study, the molecular differences between the incidences of …

Cyclooxygenase‐2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer

S Uddin, M Ahmed, A Hussain, L Assad… - … journal of cancer, 2010 - Wiley Online Library
Abstract Cyclooxygenase‐2 (COX‐2) expression contributes to tumor growth and invasion in
epithelial ovarian cancer (EOC). COX‐2 inhibitors exhibit important anticarcinogenic …

PIK3CA mutations are mutually exclusive with PTEN loss in diffuse large B-cell lymphoma

J Abubaker, PP Bavi, S Al-Harbi, AK Siraj, F Al-Dayel… - Leukemia, 2007 - nature.com
Dr S Siitonen is acknowledged for the valuable help with the flow cytometry and the
laboratory technicians in the Laboratory of Hematology, HUSLAB are acknowledged for their …

Leptin-R and its association with PI3K/AKT signaling pathway in papillary thyroid carcinoma

S Uddin, P Bavi, AK Siraj, M Ahmed… - Endocrine-related …, 2010 - erc.bioscientifica.com
The putative role of leptin and its receptor (Ob-R) in the pathogenesis of various primary
human malignancies has been reported; however, their role in papillary thyroid cancer …