User profiles for "author:G Burnstock"

Geoffrey Burnstock

University College Medical School, University College London
Verified email at ucl.ac.uk
Cited by 142762

Is there a basis for distinguishing two types of P2-purinoceptor?

G Burnstock, C Kennedy - General Pharmacology: The Vascular System, 1985 - Elsevier
1.| It is suggested that the P 2-purinoceptor may be separated into two subtypes largely on
the basis of the rank order of agonist potency of structural analogues of ATP and also on the …

International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy

MP Abbracchio, G Burnstock, JM Boeynaems… - Pharmacological …, 2006 - ASPET
There have been many advances in our knowledge about different aspects of P2Y receptor
signaling since the last review published by our International Union of Pharmacology …

Receptors for purines and pyrimidines

V Ralevic, G Burnstock - Pharmacological reviews, 1998 - ASPET
Extracellular purines (adenosine, ADP, and ATP) and pyrimidines (UDP and UTP) are
important signaling molecules that mediate diverse biological effects via cellsurface …

The Concise Guide to PHARMACOLOGY 2021/22: G protein‐coupled receptors

…, H Bräuner‐Osborne, G Burnstock… - British journal of …, 2021 - Wiley Online Library
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial
publications. The Concise Guide provides concise overviews, mostly in tabular format, of the …

Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non-adrenergic inhibitory nerves in the gut

G Burnstock, G Campbell, D Satchell… - British journal of …, 1970 - ncbi.nlm.nih.gov
Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance
released by non-adrenergic inhibitory Page 1 Br. J. Pharmac. (1970), 40, 668-688. Evidence …

Purine and pyrimidine receptors

G Burnstock - Cellular and molecular life sciences, 2007 - Springer
Adenosine 5′-triphosphate (ATP), in addition to its intracellular roles, acts as an
extracellular signalling molecule via a rich array of receptors, which have been cloned and …

Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice

…, L Kassotakis, L Hedley, WG Lachnit, G Burnstock… - Nature, 2000 - nature.com
Extracellular ATP is implicated in numerous sensory processes ranging from the response to
pain to the regulation of motility in visceral organs. The ATP receptor P2X3 is selectively …

Physiology and pathophysiology of purinergic neurotransmission

G Burnstock - Physiological reviews, 2007 - journals.physiology.org
This review is focused on purinergic neurotransmission, ie, ATP released from nerves as a
transmitter or cotransmitter to act as an extracellular signaling molecule on both pre-and …

[HTML][HTML] VI. Nomenclature and classification of purinoceptors

BB Fredholm, MP Abbracchio, G Burnstock… - Pharmacological …, 1994 - ncbi.nlm.nih.gov
“Receptors recognize a distinct chemical entity and translate information from that entity into
a form that the cell can read to alter its state”(Kenakin et al., 1992). Even though the …

Cellular distribution and functions of P2 receptor subtypes in different systems

G Burnstock, GE Knight - Int Rev Cytol, 2004 - books.google.com
This review is aimed at providing readers with a comprehensive reference article about the
distribution and function of P2 receptors in all the organs, tissues, and cells in the body …