The gut immune system has the challenge of responding to pathogens while remaining
relatively unresponsive to food antigens and the commensal microflora. In the developed …

As crucial interface organs gut and skin have much in common. Therefore it is unsurprising
that several gut pathologies have skin co‐morbidities. Nevertheless, the reason for this …

The gastrointestinal tract is the largest immune interface with the environment. Exposure to
large numbers of dietary and microbial antigens requires complex and highly regulated …

Abstract CD4+ CD25+ regulatory cells are a subpopulation of T lymphocytes of thymic
origin. However, recent data suggest an alternative commitment of regulatory T cells in the …

Colorectal cancers (CRCs) often show a dense infiltrate of cytokine-producing
immune/inflammatory cells. The exact contribution of each immune cell subset and cytokine …

BACKGROUND & AIMS: Cell-mediated immunity is a feature of Crohn's disease (CD). The
heterodimer interleukin (IL)-12, produced by phagocytes, induces T-cell cytokines, primarily …

BACKGROUND & AIMS: The pathogenesis of inflammatory bowel disease (IBD) is believed
to involve an altered balance between effector and regulatory T cells. Aryl hydrocarbon …

TGF-β1 functions as a negative regulator of T cell immune responses, signaling to target
cells using the Smad family of proteins. We show here that Smad7, an inhibitor of TGF-β1 …

Background Crohn's disease–related inflammation is characterized by reduced activity of
the immunosuppressive cytokine transforming growth factor β1 (TGF-β1) due to high levels …

Background and Aims: Interleukin 17 (IL17) is now known to be involved in a number of
chronic inflammatory disorders. However, the mechanisms regulating its production in …