Crohn's disease is a lifelong disease arising from an interaction between genetic and
environmental factors, but observed predominantly in developed countries of the world. The …

The vagus nerve represents the main component of the parasympathetic nervous system,
which oversees a vast array of crucial bodily functions, including control of mood, immune …

Inflammatory bowel diseases (IBDs) are systemic diseases that manifest not only in the gut
and gastrointestinal tract, but also in the extraintestinal organs in many patients. The quality …

The management of patients with IBD requires evaluation with objective tools, both at the
time of diagnosis and throughout the course of the disease, to determine the location …

Background & Aims: Bacterial wall products play an important role in the activation of
immune and nonimmune cells of the intestinal mucosa. Toll-like receptors (TLRs) TLR2 and …

Nuclear factor-kappa B (NF-kappaB)/Rel transcription factors play an important role in the
inducible regulation of a variety of genes involved in the inflammatory and proliferative …

This paper is the second in a series of two publications relating to the European Crohn's and
Colitis Organisation [ECCO] evidence-based consensus on the diagnosis and management …

Background & Aims: Transcription factors of the nuclear factor κB (NF-κB) family play an
important role in the regulation of genes involved in inflammation. In inflammatory bowel …

Background The global prevalence of ulcerative colitis is increasing, and induction and
maintenance of remission is a crucial therapeutic goal. We assessed the efficacy and safety …

Extraintestinal manifestations (EIM) in inflammatory bowel disease (IBD) are frequent and
may occur before or after IBD diagnosis. EIM may impact the quality of life for patients with …