Background Patients with familial adenomatous polyposis have a nearly 100 percent risk of
colorectal cancer. In this disease, the chemopreventive effects of nonsteroidal …

Background Experimental studies in animals and observational studies in humans suggest
that regular aspirin use may decrease the risk of colorectal adenomas, the precursors to …

To characterize type 2 diabetes (T2D)-associated variation across the allele frequency
spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D …

Background: Non-selective cyclooxygenase (COX) inhibitors (non-steroidal anti-
inflammatory drugs) inhibit large bowel carcinogenesis in patients with familial …

Background—Infection of pancreatic necrosis has a major impact on clinical course,
management, and outcome in acute pancreatitis. Currently, guided fine needle aspiration is …

Overview Colorectal cancer (CRC) is the third most frequently diagnosed cancer in men and
women in the United States. In 2009, an estimated 106,100 new cases of colon cancer and …

We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases
and 57,574 controls of European ancestry. We identified 49 distinct association signals at …

Hypothesis Interleukin 6 (IL-6), a multifunctional cytokine, is expressed by various cells after
many stimuli and underlies complex regulatory control mechanisms. Following major …

Therapeutic options for severe hepatic veno-occlusive disease (VOD) are limited and
outcomes are dismal, but early phase I/II studies have suggested promising activity and …

Hepatic veno-occlusive disease (VOD), also called sinusoidal obstruction syndrome (SOS),
is a potentially life-threatening complication of hematopoietic stem cell transplantation …