User profiles for "author:Gabriella Castoria"
Gabriella CastoriaProfessore di Patologia Generale- Seconda Università di Napoli Verified email at unina2.it Cited by 9582 |
[HTML][HTML] ROS in cancer therapy: the bright side of the moon
Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have
evolved as regulators of important signaling pathways. It is now well accepted that moderate …
evolved as regulators of important signaling pathways. It is now well accepted that moderate …
Recent advances on bisphenol-A and endocrine disruptor effects on human prostate cancer
M Di Donato, G Cernera, P Giovannelli… - Molecular and cellular …, 2017 - Elsevier
Endocrine disrupting chemicals (EDCs) are man-made substances widespread in the
environment that include, among many others, bisphenol A (BPA), organochlorinated …
environment that include, among many others, bisphenol A (BPA), organochlorinated …
[HTML][HTML] Estrogens and their receptors in prostate cancer: therapeutic implications
E Di Zazzo, G Galasso, P Giovannelli… - Frontiers in …, 2018 - frontiersin.org
A major challenge in clinical management of prostate cancer (PC) is to limit tumor growth
and prevent metastatic spreading. Considerable efforts have been made to discover new …
and prevent metastatic spreading. Considerable efforts have been made to discover new …
Tyrosine kinase/p21ras/MAP‐kinase pathway activation by estradiol‐receptor complex in MCF‐7 cells.
The mechanism by which estradiol acts on cell multiplication is still unclear. Under
conditions of estradiol‐dependent growth, estradiol treatment of human mammary cancer …
conditions of estradiol‐dependent growth, estradiol treatment of human mammary cancer …
[HTML][HTML] Steroid‐induced androgen receptor–oestradiol receptor β–Src complex triggers prostate cancer cell proliferation
Abstract Treatment of human prostate carcinoma‐derived LNCaP cells with androgen or
oestradiol triggers simultaneous association of androgen receptor and oestradiol receptor β …
oestradiol triggers simultaneous association of androgen receptor and oestradiol receptor β …
[HTML][HTML] Activation of the Src/p21ras/Erk pathway by progesterone receptor via cross-talk with estrogen receptor
The molecular mechanisms by which ovarian hormones stimulate growth of breast tumors
are unclear. It has been reported previously that estrogens activate the signal-transducing …
are unclear. It has been reported previously that estrogens activate the signal-transducing …
[HTML][HTML] PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells
The p85-associated phosphatidylinositol (PI) 3-kinase/Akt pathway mediates the oestradiol-
induced S-phase entry and cyclin D1 promoter activity in MCF-7 cells. Experiments with Src …
induced S-phase entry and cyclin D1 promoter activity in MCF-7 cells. Experiments with Src …
[HTML][HTML] Non-transcriptional action of oestradiol and progestin triggers DNA synthesis
G Castoria, MV Barone, M Di Domenico… - The EMBO …, 1999 - embopress.org
The recent findings that oestradiol and progestins activate the Src/Ras/Erk s signalling
pathway raise the question of the role of this stimulation. Microinjection experiments of …
pathway raise the question of the role of this stimulation. Microinjection experiments of …
Steroid receptor regulation of epidermal growth factor signaling through Src in breast and prostate cancer cells: steroid antagonist action
Under conditions of short-term hormone deprivation, epidermal growth factor (EGF) induces
DNA synthesis, cytoskeletal changes, and Src activation in MCF-7 and LNCaP cells. These …
DNA synthesis, cytoskeletal changes, and Src activation in MCF-7 and LNCaP cells. These …
Estradiol activation of human colon carcinoma-derived Caco-2 cell growth
This is the first report on estrogen-dependent growth of human-derived colon carcinoma
cells. Under selected conditions, growth of subconfluent Caco-2 cells is triggered by …
cells. Under selected conditions, growth of subconfluent Caco-2 cells is triggered by …