User profiles for "author:Gabriella Castoria"

Gabriella Castoria

Professore di Patologia Generale- Seconda Università di Napoli
Verified email at unina2.it
Cited by 9582

[HTML][HTML] ROS in cancer therapy: the bright side of the moon

B Perillo, M Di Donato, A Pezone, E Di Zazzo… - … & molecular medicine, 2020 - nature.com
Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have
evolved as regulators of important signaling pathways. It is now well accepted that moderate …

Recent advances on bisphenol-A and endocrine disruptor effects on human prostate cancer

M Di Donato, G Cernera, P Giovannelli… - Molecular and cellular …, 2017 - Elsevier
Endocrine disrupting chemicals (EDCs) are man-made substances widespread in the
environment that include, among many others, bisphenol A (BPA), organochlorinated …

[HTML][HTML] Estrogens and their receptors in prostate cancer: therapeutic implications

E Di Zazzo, G Galasso, P Giovannelli… - Frontiers in …, 2018 - frontiersin.org
A major challenge in clinical management of prostate cancer (PC) is to limit tumor growth
and prevent metastatic spreading. Considerable efforts have been made to discover new …

Tyrosine kinase/p21ras/MAP‐kinase pathway activation by estradiol‐receptor complex in MCF‐7 cells.

A Migliaccio, M Di Domenico, G Castoria… - The EMBO …, 1996 - embopress.org
The mechanism by which estradiol acts on cell multiplication is still unclear. Under
conditions of estradiol‐dependent growth, estradiol treatment of human mammary cancer …

[HTML][HTML] Steroid‐induced androgen receptor–oestradiol receptor β–Src complex triggers prostate cancer cell proliferation

A Migliaccio, G Castoria, M Di Domenico… - The EMBO …, 2000 - embopress.org
Abstract Treatment of human prostate carcinoma‐derived LNCaP cells with androgen or
oestradiol triggers simultaneous association of androgen receptor and oestradiol receptor β …

[HTML][HTML] Activation of the Src/p21ras/Erk pathway by progesterone receptor via cross-talk with estrogen receptor

A Migliaccio, D Piccolo, G Castoria… - The EMBO …, 1998 - embopress.org
The molecular mechanisms by which ovarian hormones stimulate growth of breast tumors
are unclear. It has been reported previously that estrogens activate the signal-transducing …

[HTML][HTML] PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells

G Castoria, A Migliaccio, A Bilancio… - The EMBO …, 2001 - embopress.org
The p85-associated phosphatidylinositol (PI) 3-kinase/Akt pathway mediates the oestradiol-
induced S-phase entry and cyclin D1 promoter activity in MCF-7 cells. Experiments with Src …

[HTML][HTML] Non-transcriptional action of oestradiol and progestin triggers DNA synthesis

G Castoria, MV Barone, M Di Domenico… - The EMBO …, 1999 - embopress.org
The recent findings that oestradiol and progestins activate the Src/Ras/Erk s signalling
pathway raise the question of the role of this stimulation. Microinjection experiments of …

Steroid receptor regulation of epidermal growth factor signaling through Src in breast and prostate cancer cells: steroid antagonist action

A Migliaccio, M Di Domenico, G Castoria… - Cancer research, 2005 - AACR
Under conditions of short-term hormone deprivation, epidermal growth factor (EGF) induces
DNA synthesis, cytoskeletal changes, and Src activation in MCF-7 and LNCaP cells. These …

Estradiol activation of human colon carcinoma-derived Caco-2 cell growth

M Di Domenico, G Castoria, A Bilancio, A Migliaccio… - Cancer Research, 1996 - AACR
This is the first report on estrogen-dependent growth of human-derived colon carcinoma
cells. Under selected conditions, growth of subconfluent Caco-2 cells is triggered by …