Cellular senescence is a fundamental, complex mechanism with an important protective role
present from embryogenesis to late life across all species. It limits the proliferative potential …

The successful use of orthotopic liver transplantation in fulminant hepatic failure has created
a need for early prognostic indicators to select the patients most likely to benefit at a time …

Background. When administered early after an overdose of acetaminophen, intravenous
acetylcysteine prevents hepatic necrosis by replenishing reduced stores of glutathione. How …

Abnormalities of carbohydrate metabolism, including hyperinsulinaemia and insulin
resistance, are well recognised complications of cirrhosis. While diabetes mellitus can be …

Non-insulin-dependent diabetes mellitus (NIDDM) may be associated with chronic hepatitis
C virus (HCV) infection. This was studied further in two parts. First, 1,151 patients with HCV …

Long‐term follow‐up of 27 patients with hepatitis B virus—related chronic liver disease
treated by transplantation showed that 23 had hepatitis B virus recurrence. In 13 patients …

The implications of hepatitis B virus (HBV) reinfection after liver transplantation were studied
in 29 patients followed for 1.7–15 years. Of 20 patients with HBV infection alone, nine were …

Hepatocellular carcinoma (HCC) has a poor prognosis with limited therapeutic options. We
propose that local immune responses in patients with HCC are held in check by tumor …

The basis of chronic infection following exposure to hepatitis C virus (HCV) infection is
unexplained. One factor may be the low frequency and immature phenotype of virus-specific …

Primary biliary cholangitis (formerly known as primary biliary cirrhosis, PBC) is an
autoimmune liver disease in which a cycle of immune mediated biliary epithelial cell injury …