Recent progress in cancer immunotherapy emphasizes the importance of understanding
immune-regulatory pathways in tumours. Dysfunction of antitumour T cells may be due to …

Inhibitory receptors (iRs) are frequently associated with “T cell exhaustion”. However, the
expression of iRs is also dependent on T cell differentiation and activation. Therapeutic …

Simple Summary Tumor-associated macrophages (TAMs) play major roles in solid tumor
development. They can have both anti-tumor and pro-tumor properties depending on their …

Objective In this study, we determined whether Helicobacter pylori (H. pylori) infection
dampens the efficacy of cancer immunotherapies. Design Using mouse models, we …

Group 2 innate lymphoid cells (ILC2s) are involved in human diseases, such as allergy,
atopic dermatitis and nasal polyposis, but their function in human cancer remains unclear …

Background Several mechanisms are present in the tumor microenvironment (TME) to
impair cytotoxic T cell responses potentially able to control tumor growth. Among these, the …

T cells infiltrating neoplasms express surface molecules typical of chronically virus‐
stimulated T cells, often termed “exhausted” T cells. We compared the transcriptome of …

The transcription factor NF-κB is central to inflammatory signaling and activation of innate
and adaptive immune responses. Activation of the NF-κB pathway is tightly controlled by …

A major limiting factor in the success of immunotherapy is tumor infiltration by CD8+ T cells,
a process that remains poorly understood. In the present study, we characterized homing …

Innate immunity is considered to initiate adaptive antitumor responses. We demonstrate that
monoclonal CD8 T lymphocytes reactive to tumor Ag P1A on P815 mastocytoma cells …