Helicobacter pylori (H. pylori) infection plays a crucial role in the development of gastric
cancer. There are two major pathways for the development of gastric cancer by H. pylori …

Clonal expansion in aged normal tissues has been implicated in the development of cancer.
However, the chronology and risk dependence of the expansion are poorly understood …

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death since
most patients are diagnosed at advanced stage and the current systemic treatment options …

Signal transduction and activator of transcription 3 (STAT3) signaling is constitutively
activated in various tumors, and is involved in cell survival and proliferation during …

The development of immune checkpoint inhibitors (ICIs) targeting cytotoxic T lymphocyte
antigen 4 (CTLA-4), programmed cell death protein 1 (PD-1), or programmed cell death …

There is great interest in tumor stem cells (TSCs) as potential therapeutic targets; however,
cancer therapies targeting TSCs are limited. A drawback is that TSC markers are often …

Musashi‐1, a neural RNA‐binding protein, is important for maintaining neural stem cells.
Both Musashi‐1 and Hes1, a transcriptional factor regulated by Musashi‐1, are expressed in …

The colonic epithelial lining undergoes constant replacement, driven by epithelial stem cells
in crypts of Lieberkühn. Stem cells lost because of damage or disease can be replaced by …

Lgr5+ adult intestinal stem cells are highly proliferative throughout life. Single Lgr5+ stem
cells can be cultured into three-dimensional organoids containing all intestinal epithelial cell …

To investigate angiogenesis during intestinal polyp development, we determined the
microvessel density (MVD) in polyps of Apc knockout (Apc Δ 716) mice, a model for human …