The highly variable solar extreme ultraviolet (EUV) radiation is the major energy input to the
Earth's upper atmosphere, strongly impacting the geospace environment, affecting satellite …

Once Medawar (76) had established the immunological basis of the allograft reaction, tissue
antigen was seen to be the barrier to the grafting of tissues and organs. At the root of this …

Sepsis, a common and potentially fatal systemic illness, is triggered by microbial infection
and often leads to impaired function of the lungs, kidneys or other vital organs. Since the …

A cornerstone of modern biomedical research is the use of mouse models to explore basic
pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no …

Despite significant advances in intensive care therapy and antibiotics, severe sepsis
accounts for 9% of all deaths in the United States annually. The pathological sequelae of …

Abstract The Transition Region and Coronal Explorer (TRACE) satellite, launched 2 April
1998, is a NASA Small Explorer (SMEX) that images the solar photosphere, transition region …

Human survival from injury requires an appropriate inflammatory and immune response. We
describe the circulating leukocyte transcriptome after severe trauma and burn injury, as well …

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular
disease. We report the largest genetic association study of blood pressure traits (systolic …

Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied
prevalence worldwide owing to different dietary patterns and medication use. Despite …

Elevated blood pressure is the leading heritable risk factor for cardiovascular disease
worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse …