Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles
The prospect of improved cancer chemotherapy using solid lipid nanoparticles (SLN) as a
drug delivery system is promising. Several obstacles frequently encountered with anticancer …
drug delivery system is promising. Several obstacles frequently encountered with anticancer …
Nanotechnological advances for the delivery of CNS therapeutics
Effective non-invasive treatment of neurological diseases is often limited by the poor access
of therapeutic agents into the central nervous system (CNS). The majority of drugs and …
of therapeutic agents into the central nervous system (CNS). The majority of drugs and …
Current approaches to enhance CNS delivery of drugs across the brain barriers
CT Lu, YZ Zhao, HL Wong, J Cai, L Peng… - International journal of …, 2014 - Taylor & Francis
Although many agents have therapeutic potentials for central nervous system (CNS)
diseases, few of these agents have been clinically used because of the brain barriers. As the …
diseases, few of these agents have been clinically used because of the brain barriers. As the …
Detection and localization of surgically resectable cancers with a multi-analyte blood test
Earlier detection is key to reducing cancer deaths. Here, we describe a blood test that can
detect eight common cancer types through assessment of the levels of circulating proteins …
detect eight common cancer types through assessment of the levels of circulating proteins …
Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer
Detection of circulating tumor DNA (ctDNA) after resection of stage II colon cancer may
identify patients at the highest risk of recurrence and help inform adjuvant treatment …
identify patients at the highest risk of recurrence and help inform adjuvant treatment …
[HTML][HTML] Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials
Substantial COVID-19 research investment has been allocated to randomized clinical trials
(RCTs) on hydroxychloroquine/chloroquine, which currently face recruitment challenges or …
(RCTs) on hydroxychloroquine/chloroquine, which currently face recruitment challenges or …
[HTML][HTML] Circulating tumor DNA as an early marker of therapeutic response in patients with metastatic colorectal cancer
J Tie, I Kinde, Y Wang, HL Wong, J Roebert… - Annals of …, 2015 - Elsevier
Background Early indicators of treatment response in metastatic colorectal cancer (mCRC)
could conceivably be used to optimize treatment. We explored early changes in circulating …
could conceivably be used to optimize treatment. We explored early changes in circulating …
Hd3a protein is a mobile flowering signal in rice
Florigen, the mobile signal that moves from an induced leaf to the shoot apex and causes
flowering, has eluded identification since it was first proposed 70 years ago. Understanding …
flowering, has eluded identification since it was first proposed 70 years ago. Understanding …
Transforming growth factor-beta is a potent immunosuppressive agent that inhibits IL-1-dependent lymphocyte proliferation.
SM Wahl, DA Hunt, HL Wong, S Dougherty… - … (Baltimore, Md.: 1950 …, 1988 - journals.aai.org
Transforming growth factor-beta (TGF-beta), a product of neoplastic and hemopoietic cells,
is a bifunctional regulator of the immune response. At femtomolar concentrations, TGF-beta …
is a bifunctional regulator of the immune response. At femtomolar concentrations, TGF-beta …
Response of a rigid foundation to a spatially random ground motion
JE Luco, HL Wong - Earthquake Engineering & Structural …, 1986 - Wiley Online Library
A method to obtain the dynamic response of an extended rigid foundation supported on an
elastic half‐space when subjected to a spatially varying ground motion including both …
elastic half‐space when subjected to a spatially varying ground motion including both …