A simple diet-and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer

T Tsuchida, YA Lee, N Fujiwara, M Ybanez, B Allen… - Journal of …, 2018 - Elsevier
Background and Aims Although the majority of patients with non-alcoholic fatty liver disease
(NAFLD) have only steatosis without progression, a sizeable fraction develop non-alcoholic …

Attendance of board meetings and company performance: Evidence from Taiwan

HI Chou, H Chung, X Yin - Journal of Banking & Finance, 2013 - Elsevier
This paper empirically investigates board meeting attendance and its effects on the
performance of Taiwanese listed corporations. Directors with higher qualifications attend …

[HTML][HTML] Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap

YA Lee, LA Noon, KM Akat, MD Ybanez, TF Lee… - Nature …, 2018 - nature.com
Activation of the Hippo pathway effector Yap underlies many liver cancers, however no
germline or somatic mutations have been identified. Autophagy maintains essential …

A hepatic stellate cell gene expression signature associated with outcomes in hepatitis C cirrhosis and hepatocellular carcinoma after curative resection

DY Zhang, N Goossens, J Guo, MC Tsai, HI Chou… - Gut, 2016 - gut.bmj.com
Objective We used an informatics approach to identify and validate genes whose expression
is unique to hepatic stellate cells and assessed the prognostic capability of their expression …

[HTML][HTML] The XBP1 arm of the unfolded protein response induces fibrogenic activity in hepatic stellate cells through autophagy

RS Kim, D Hasegawa, N Goossens, T Tsuchida… - Scientific reports, 2016 - nature.com
Autophagy and the unfolded protein response (UPR) both promote activation of hepatic
stellate cells (HSC), however the link between the two stimuli remains unclear. Here we …

The effects of financial distress and capital structure on the work effort of outside directors

HI Chou, H Li, X Yin - Journal of Empirical Finance, 2010 - Elsevier
This paper investigates the conflict of interests between shareholders and debtholders by
examining the work effort of outside directors when a company experiences financial …

Innovation or dividend payout: Evidence from China

B Yang, HI Chou, J Zhao - International Review of Economics & Finance, 2020 - Elsevier
Abstract Since 2001, the China Securities Regulatory Commission has implemented a
series of policies to ensure that dividend payments constitute a prerequisite of equity …

Epithelial Xbp1 is required for cellular proliferation and differentiation during mammary gland development

D Hasegawa, V Calvo, A Avivar-Valderas… - … and cellular biology, 2015 - Taylor & Francis
Xbp1, a key mediator of the unfolded protein response (UPR), is activated by IRE1α-
mediated splicing, which results in a frameshift to encode a protein with transcriptional …

Anti‐fibrotic activity and enhanced interleukin‐6 production by hepatic stellate cells in response to imatinib mesylate

Y Kim, MI Fiel, E Albanis, HI Chou, W Zhang… - Liver …, 2012 - Wiley Online Library
Objective To examine imatinib mesylate's effects on stellate cell responses in vivo and in
vitro. The hepatic stellate cell (HSC) is a key target of anti‐fibrotic therapies. Imatinib …

Are all regulatory compliant independent director appointments the same? An analysis of Taiwanese board appointments

HI Chou, PA Hamill, YH Yeh - Journal of Corporate Finance, 2018 - Elsevier
Globally many regulators adopted a rules-based approach to independent director
appointments stipulating 'independence'criteria. This paper investigates whether partitioning …