Domain antibodies: proteins for therapy

LJ Holt, C Herring, LS Jespers, BP Woolven… - TRENDS in …, 2003 - cell.com
Occurring naturally in 'heavy chain'immunoglobulins from camels, and now produced in fully
human form, domain antibodies (dAbs) are the smallest known antigen-binding fragments of …

Genetic prognostic and predictive markers in colorectal cancer

A Walther, E Johnstone, C Swanton, R Midgley… - Nature Reviews …, 2009 - nature.com
Despite many studies of the likely survival outcome of individual patients with colorectal
cancer, our knowledge of this subject remains poor. Until recently, we had virtually no …

Mitochondrial tumour suppressors: a genetic and biochemical update

E Gottlieb, IPM Tomlinson - Nature Reviews Cancer, 2005 - nature.com
Since the discovery 5 years ago that the D-subunit of succinate dehydrogenase (SDHD) can
behave as a classic tumour suppressor, other nuclear-encoded mitochondrial proteins …

Large-scale genotyping identifies 41 new loci associated with breast cancer risk

K Michailidou, P Hall, A Gonzalez-Neira… - Nature …, 2013 - nature.com
Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for∼ …

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

IPM Tomlinson, NA Alam, AJ Rowan, E Barclay… - Nature …, 2002 - nature.com
Uterine leiomyomata (fibroids) are common and clinically important tumors, but little is
known about their etiology and pathogenesis 1, 2, 3. We previously mapped a gene that …

A serine/threonine kinase gene defective in Peutz–Jeghers syndrome

A Hemminki, D Markie, I Tomlinson, E Avizienyte… - Nature, 1998 - nature.com
Studies of hereditary cancer syndromes have contributed greatly to our understanding of
molecular events involved in tumorigenesis. Here we investigate the molecular background …

A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24. 21

I Tomlinson, E Webb, L Carvajal-Carmona… - Nature …, 2007 - nature.com
Much of the variation in inherited risk of colorectal cancer (CRC) is probably due to
combinations of common low risk variants. We conducted a genome-wide association study …

Mutations in the SMAD4/DPC4 Gene in Juvenile Polyposis

JR Howe, S Roth, JC Ringold, RW Summers… - Science, 1998 - science.org
Familial juvenile polyposis is an autosomal dominant disease characterized by a
predisposition to hamartomatous polyps and gastrointestinal cancer. Here it is shown that a …

[HTML][HTML] Multiple Colorectal Adenomas, Classic Adenomatous Polyposis, and Germ-Line Mutations in MYH

OM Sieber, L Lipton, M Crabtree… - … England Journal of …, 2003 - Mass Medical Soc
Background Germ-line mutations in the base-excision–repair gene MYH have been
associated with recessive inheritance of multiple colorectal adenomas. Tumors from affected …

The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops

IM Tomlinson, G Walter, JD Marks, MB Llewelyn… - Journal of molecular …, 1992 - Elsevier
We have used the polymerase chain reaction and VH family-based primers to clone and
sequence 74 human germline VH segments from a single individual and built a directory to …