Domain antibodies: proteins for therapy
LJ Holt, C Herring, LS Jespers, BP Woolven… - TRENDS in …, 2003 - cell.com
Occurring naturally in 'heavy chain'immunoglobulins from camels, and now produced in fully
human form, domain antibodies (dAbs) are the smallest known antigen-binding fragments of …
human form, domain antibodies (dAbs) are the smallest known antigen-binding fragments of …
Genetic prognostic and predictive markers in colorectal cancer
Despite many studies of the likely survival outcome of individual patients with colorectal
cancer, our knowledge of this subject remains poor. Until recently, we had virtually no …
cancer, our knowledge of this subject remains poor. Until recently, we had virtually no …
Mitochondrial tumour suppressors: a genetic and biochemical update
E Gottlieb, IPM Tomlinson - Nature Reviews Cancer, 2005 - nature.com
Since the discovery 5 years ago that the D-subunit of succinate dehydrogenase (SDHD) can
behave as a classic tumour suppressor, other nuclear-encoded mitochondrial proteins …
behave as a classic tumour suppressor, other nuclear-encoded mitochondrial proteins …
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
K Michailidou, P Hall, A Gonzalez-Neira… - Nature …, 2013 - nature.com
Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for∼ …
been identified as associated with susceptibility to breast cancer, and these account for∼ …
Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer
IPM Tomlinson, NA Alam, AJ Rowan, E Barclay… - Nature …, 2002 - nature.com
Uterine leiomyomata (fibroids) are common and clinically important tumors, but little is
known about their etiology and pathogenesis 1, 2, 3. We previously mapped a gene that …
known about their etiology and pathogenesis 1, 2, 3. We previously mapped a gene that …
A serine/threonine kinase gene defective in Peutz–Jeghers syndrome
A Hemminki, D Markie, I Tomlinson, E Avizienyte… - Nature, 1998 - nature.com
Studies of hereditary cancer syndromes have contributed greatly to our understanding of
molecular events involved in tumorigenesis. Here we investigate the molecular background …
molecular events involved in tumorigenesis. Here we investigate the molecular background …
A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24. 21
I Tomlinson, E Webb, L Carvajal-Carmona… - Nature …, 2007 - nature.com
Much of the variation in inherited risk of colorectal cancer (CRC) is probably due to
combinations of common low risk variants. We conducted a genome-wide association study …
combinations of common low risk variants. We conducted a genome-wide association study …
Mutations in the SMAD4/DPC4 Gene in Juvenile Polyposis
JR Howe, S Roth, JC Ringold, RW Summers… - Science, 1998 - science.org
Familial juvenile polyposis is an autosomal dominant disease characterized by a
predisposition to hamartomatous polyps and gastrointestinal cancer. Here it is shown that a …
predisposition to hamartomatous polyps and gastrointestinal cancer. Here it is shown that a …
[HTML][HTML] Multiple Colorectal Adenomas, Classic Adenomatous Polyposis, and Germ-Line Mutations in MYH
OM Sieber, L Lipton, M Crabtree… - … England Journal of …, 2003 - Mass Medical Soc
Background Germ-line mutations in the base-excision–repair gene MYH have been
associated with recessive inheritance of multiple colorectal adenomas. Tumors from affected …
associated with recessive inheritance of multiple colorectal adenomas. Tumors from affected …
The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops
IM Tomlinson, G Walter, JD Marks, MB Llewelyn… - Journal of molecular …, 1992 - Elsevier
We have used the polymerase chain reaction and VH family-based primers to clone and
sequence 74 human germline VH segments from a single individual and built a directory to …
sequence 74 human germline VH segments from a single individual and built a directory to …