This study investigated the combined effect of neonatal maternal separation and acute
psychological stress on pain responses in adult rats. Long-Evans dams and their male pups …

Inflammatory proteases (mast cell tryptase and trypsins) cleave protease-activated receptor
2 (PAR2) on spinal afferent neurons and cause persistent inflammation and hyperalgesia by …

Chronic stress plays an important role in the development and exacerbation of symptoms in
functional gastrointestinal disorders. To better understand the mechanisms underlying this …

A human colonic epithelial cell line, T84, derived from a colonic carcinoma, has been
examined both morphologically and functionally. The cells grew to confluence as a …

Background & Aims: N-methyl-d-aspartate (NMDA) receptors are ligand-gated ion channels
that have an important role in long-term potentiation and memory processing in the central …

Separate breeding colonies of C57BL/6 (“B6”) mice maintained at the Jackson Laboratories
(“J”) and NIH (“N”) have led to the emergence of two distinct substrains of C57BL/6 mice …

Patients with functional gastrointestinal disorders (FGIDs) often experience distress, reduced
quality of life, a perceived lack of validation, and an unsatisfactory experience with health …

Abstract N‐methyl‐D‐aspartate (NMDA) receptors in sensory afferents participate in chronic
pain by mediating peripheral and central sensitization. We studied the presence of NMDA …

NMDA receptors in primary afferent terminals can contribute to hyperalgesia by increasing
neurotransmitter release. In rats and mice, we found that the ability of intrathecal NMDA to …

Both irritable bowel syndrome and inflammatory bowel diseases share symptoms of altered
bowel habits associated with abdominal pain or discomfort. Irritable bowel syndrome has …