Activation of the NLRP3 inflammasome and subsequent maturation of IL-1β have been
implicated in acute lung injury (ALI), resulting in inflammation and fibrosis. We investigated …

Background & Aims: Adiponectin (APN) is an adipokine that regulates insulin sensitivity and
is anti-inflammatory in atherosclerosis. The goal of this study was to investigate the role of …

Rationale: Wnt/β-catenin signaling has been implicated in lung fibrosis, but how this occurs
and whether expression changes in Wnt pathway components predict disease progression …

Background: Leptin regulates appetite through the long isoform of its receptor in the
hypothalamus. Although leptin regulates immune responses, it is still unknown whether a …

Previous studies established that attenuating Wnt/β-catenin signaling limits lung fibrosis in
the bleomycin mouse model of this disease, but the contribution of this pathway to distinct …

Concanavalin A-induced hepatotoxicity was compared in lipodystrophic aP2-nSREBP-1c
transgenic mice (LD mice) lacking adipose tissue, obese leptin-deficient ob/ob mice, and …

Obesity is associated with increased severity of acute pancreatitis (AP). The cytokines IL-18
and IL-12 are elevated in patients with AP, and IL-18 levels are high in obesity. We aimed to …

Leptin-deficient ob/ob mice exhibit several metabolic and immune abnormalities, including
thymus atrophy and markedly reduced inflammatory responses. We evaluated whether …

Obesity is associated with increased severity of acute pancreatitis (AP). We recently
developed a model of AP induced by administration of interleukin (IL)‐12+ IL‐18, two …

The transcription factor IFN regulatory factor‐1 (IRF‐1) regulates production and activity of
many inflammatory mediators and cells. Here, we investigated the role of IRF‐1 in intestinal …