Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios
JA Williams, R Hyland, BC Jones, DA Smith… - Drug Metabolism and …, 2004 - ASPET
Glucuronidation is a listed clearance mechanism for 1 in 10 of the top 200 prescribed drugs.
The objective of this article is to encourage those studying ligand interactions with UDP …
The objective of this article is to encourage those studying ligand interactions with UDP …
[HTML][HTML] Mitochondrial dynamics and mitochondrial quality control
Mitochondria are cellular energy powerhouses that play important roles in maintaining cell
survival, cell death and cellular metabolic homeostasis. Timely removal of damaged …
survival, cell death and cellular metabolic homeostasis. Timely removal of damaged …
Origin and evolution of high throughput screening
DA Pereira, JA Williams - British journal of pharmacology, 2007 - Wiley Online Library
This article reviews the origin and evolution of high throughput screening (HTS) through the
experience of an individual pharmaceutical company, revealing some of the mysteries of the …
experience of an individual pharmaceutical company, revealing some of the mysteries of the …
High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response
H Gao, JM Korn, S Ferretti, JE Monahan, Y Wang… - Nature medicine, 2015 - nature.com
Profiling candidate therapeutics with limited cancer models during preclinical development
hinders predictions of clinical efficacy and identifying factors that underlie heterogeneous …
hinders predictions of clinical efficacy and identifying factors that underlie heterogeneous …
Positron Emission Tomography Reveals Elevated D2 Dopamine Receptors in Drug-Naive Schizophrenics
DF Wong, HN Wagner Jr, LE Tune, RF Dannals… - Science, 1986 - science.org
In postmortem studies of patients with schizophrenia, D2 dopamine receptors in the basal
ganglia have been observed to be more numerous than in patients with no history of …
ganglia have been observed to be more numerous than in patients with no history of …
[37] Carbonyl assays for determination of oxidatively modified proteins
RL Levine, JA Williams, EP Stadtman, E Shacter - Methods in enzymology, 1994 - Elsevier
Publisher Summary Enzymes and structural proteins may be attacked whenever free
radicals are generated. As a consequence, oxidative modification of proteins may occur in a …
radicals are generated. As a consequence, oxidative modification of proteins may occur in a …
[PDF][PDF] Rest in Drosophila is a sleep-like state
JC Hendricks, SM Finn, KA Panckeri, J Chavkin… - Neuron, 2000 - cell.com
To facilitate the genetic study of sleep, we documented that rest behavior in Drosophila
melanogaster is a sleep-like state. The animals choose a preferred location, become …
melanogaster is a sleep-like state. The animals choose a preferred location, become …
[HTML][HTML] PD-L1 immunohistochemistry assays for lung cancer: results from phase 1 of the blueprint PD-L1 IHC assay comparison project
FR Hirsch, A McElhinny, D Stanforth… - Journal of Thoracic …, 2017 - Elsevier
Abstract Introduction The Blueprint Programmed Death Ligand 1 (PD-L1)
Immunohistochemistry (IHC) Assay Comparison Project is an industrial-academic …
Immunohistochemistry (IHC) Assay Comparison Project is an industrial-academic …
Cholecystokinin bioactivity in human plasma. Molecular forms, responses to feeding, and relationship to gallbladder contraction.
RA Liddle, ID Goldfine, MS Rosen… - The Journal of …, 1985 - Am Soc Clin Investig
A sensitive and specific bioassay for the measurement of cholecystokinin (CCK) in human
plasma was developed to determine the molecular forms of CCK in circulation, CCK …
plasma was developed to determine the molecular forms of CCK in circulation, CCK …
Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7
JA Williams, BJ Ring, VE Cantrell, DR Jones… - Drug Metabolism and …, 2002 - ASPET
The human cytochromes P450 (P450) CYP3A contribute to the biotransformation of 50% of
oxidatively metabolized drugs. The predominant hepatic form is CYP3A4, but recent …
oxidatively metabolized drugs. The predominant hepatic form is CYP3A4, but recent …