Abstract Background The role of Th2 cells (producing interleukin (IL-) 4, IL-5 and IL-13) in
allergic asthma is well-defined. A distinct proinflammatory T cell lineage has recently been …

Interleukin (IL)-17 is produced by activated memory CD4+ cells and induces cytokines and
chemokines that stimulate neutrophil generation and recruitment. Here, we investigated the …

An intact functional mucosal barrier is considered to be crucial for the maintenance of airway
homeostasis as it protects the host immune system from exposure to allergens and noxious …

OBJECTIVES: A primary defect of the tight junctions and, hence, increased intestinal
epithelial permeability has been proposed as a basic pathogenic event in Crohn's disease …

Background: Asthma is a chronic inflammatory disorder of the airways driven by T cell
activation. Th2 cells and their cytokines are thought to play a role in the pathophysiology of …

Background Tight junction (TJ) defects have recently been associated with asthma and
chronic rhinosinusitis. The expression, function, and regulation of nasal epithelial TJs …

T cell proliferation induced by the lectin PHA requires the presence of monocytes. Here, we
report that IL-6 represents part of the monocyte-derived helper activity for human T cell …

IL-15 shares biological activities but no significant sequence homology with IL-2. It induces T
cell recruitment to sites of inflammation, T cell proliferation, and cytokine production and …

Background Allergic rhinitis (AR) is characterized by mucosal inflammation, driven by
activated immune cells. Mast cells and TH 2 cells might decrease epithelial barrier integrity …

Background: Adalimumab, a fully human monoclonal antibody to tumour necrosis factor,
was recently introduced for therapy of Crohn's disease. Aim: Since induction of apoptosis of …