Abstract Taurine (2-aminoethanesulfonic acid) is the most abundant free amino acid in
humans and plays an important role in several essential biological processes such as bile …

Myeloperoxidase (MPO) is a major protein constituent of the primary granules of vertebrate
neutrophils. It catalyses the hydrogen peroxide-mediated oxidation of halide ions to …

Proopiomelanocortin (POMC) is a precursor to various, bioactive peptides including ACTH,
βLPH, αMSH, and βendorphin (βEND). Processing of POMC at dibasic residues is tissue …

Seven secretory mammalian kexin-like subtilases have been identified that cleave a variety
of precursor proteins at monobasic and dibasic residues. The recently characterized …

The proprotein convertase PCSK9 gene is the third locus implicated in familial
hypercholesterolemia, emphasizing its role in cardiovascular diseases. Loss of function …

The gene encoding the proprotein convertase subtilisin/kexin type 9 (PCSK9) is linked to
familial hypercholesterolemia, as are those of the low‐density lipoprotein receptor (LDLR) …

Using reverse transcriptase–PCR and degenerate oligonucleotides derived from the active-
site residues of subtilisin/kexin-like serine proteinases, we have identified a highly …

The secretory factor VEGF-C has been directly implicated in various physiological processes
during embryogenesis and human cancers. However, the importance of the conversion of its …

The production of hypochlorous acid (HOCl) is a characteristic of granulocyte activation, a
hallmark of the early phase of innate immune responses. In this study, we show that, in …

Objective—Proprotein convertase subtilisin/kexin 9 (PCSK9) promotes the degradation of
the low-density lipoprotein receptor (LDLR), and its gene is the third locus implicated in …