Background: Treatment options for patients with advanced esophageal or esophagogastric
junction (EGJ) cancer are limited. Current guidelines for first-line treatment of advanced …

Background Data are lacking on the efficacy and safety of a combination chemotherapy
regimen consisting of oxaliplatin, irinotecan, fluorouracil, and leucovorin (FOLFIRINOX) as …

Vinflunine (Javlor) is the first fluorinated microtubule inhibitor belonging to the Vinca
alkaloids family. Vinflunine is obtained by semisynthesis using superacidic chemistry to …

Purpose The LUX-Lung 3 study investigated the efficacy of chemotherapy compared with
afatinib, a selective, orally bioavailable ErbB family blocker that irreversibly blocks signaling …

Background First-line nivolumab plus ipilimumab has shown improved overall survival in
patients with advanced non-small-cell lung cancer (NSCLC). We aimed to investigate …

Background We aimed to assess the effect of afatinib on overall survival of patients with
EGFR mutation-positive lung adenocarcinoma through an analysis of data from two open …

Despite curative-intent treatment, most patients with locally advanced esophageal cancer
will experience disease recurrence or locoregional progression, highlighting the need for …

Background Bevacizumab plus fluoropyrimidine-based chemotherapy is standard treatment
for first-line and bevacizumab-naive second-line metastatic colorectal cancer. We assessed …

PURPOSE Patients with advanced esophageal cancer have a poor prognosis and limited
treatment options after first-line chemotherapy. PATIENTS AND METHODS In this open …

Purpose Treatment with gemcitabine provides modest benefits in patients with metastatic
pancreatic cancer. The addition of erlotinib to gemcitabine shows a small but significant …