[HTML][HTML] Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP …
Background Microbiological characterisation of co-infections and secondary infections in
patients with COVID-19 is lacking, and antimicrobial use is high. We aimed to describe …
patients with COVID-19 is lacking, and antimicrobial use is high. We aimed to describe …
[HTML][HTML] Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study
RK Gupta, EM Harrison, A Ho, AB Docherty… - The Lancet …, 2021 - thelancet.com
Background Prognostic models to predict the risk of clinical deterioration in acute COVID-19
cases are urgently required to inform clinical management decisions. Methods We …
cases are urgently required to inform clinical management decisions. Methods We …
[HTML][HTML] Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective …
Background COVID-19 is a multisystem disease and patients who survive might have in-
hospital complications. These complications are likely to have important short-term and long …
hospital complications. These complications are likely to have important short-term and long …
[HTML][HTML] Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort …
Background Studies of patients admitted to hospital with COVID-19 have found varying
mortality outcomes associated with underlying respiratory conditions and inhaled …
mortality outcomes associated with underlying respiratory conditions and inhaled …
[HTML][HTML] Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective …
Background Early in the pandemic it was suggested that pre-existing use of non-steroidal
anti-inflammatory drugs (NSAIDs) could lead to increased disease severity in patients with …
anti-inflammatory drugs (NSAIDs) could lead to increased disease severity in patients with …
Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis
W Huang, DM Booth, MC Cane, M Chvanov, MA Javed… - Gut, 2014 - gut.bmj.com
Objective Non-oxidative metabolism of ethanol (NOME) produces fatty acid ethyl esters
(FAEEs) via carboxylester lipase (CEL) and other enzyme action implicated in mitochondrial …
(FAEEs) via carboxylester lipase (CEL) and other enzyme action implicated in mitochondrial …
[HTML][HTML] Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation …
AB Docherty, RH Mulholland, NI Lone… - The Lancet …, 2021 - thelancet.com
Background Mortality rates in hospitalised patients with COVID-19 in the UK appeared to
decline during the first wave of the pandemic. We aimed to quantify potential drivers of this …
decline during the first wave of the pandemic. We aimed to quantify potential drivers of this …
Ultrastructural study of the behavior of macrophages toward parasitic mycobacteria
PDA Hart, JA Armstrong, CA Brown… - Infection and …, 1972 - Am Soc Microbiol
Mycobacterium lepraemurium and M. microti (causal agent of vole tuberculosis) were
isolated from tissues of experimentally infected mice and used to infect normal mouse …
isolated from tissues of experimentally infected mice and used to infect normal mouse …
[HTML][HTML] Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study
F Närhi, SR Moonesinghe, SD Shenkin… - The Lancet Digital …, 2022 - thelancet.com
Background Dexamethasone was the first intervention proven to reduce mortality in patients
with COVID-19 being treated in hospital. We aimed to evaluate the adoption of …
with COVID-19 being treated in hospital. We aimed to evaluate the adoption of …
[HTML][HTML] Oxidative stress alters mitochondrial bioenergetics and modifies pancreatic cell death independently of cyclophilin D, resulting in an apoptosis-to-necrosis …
JA Armstrong, NJ Cash, Y Ouyang, JC Morton… - Journal of Biological …, 2018 - ASBMB
Mitochondrial dysfunction lies at the core of acute pancreatitis (AP). Diverse AP stimuli
induce Ca 2+-dependent formation of the mitochondrial permeability transition pore (MPTP) …
induce Ca 2+-dependent formation of the mitochondrial permeability transition pore (MPTP) …