User profiles for "author:Jared A Weis"

Jared A. Weis

Assistant Professor, Wake Forest School of Medicine
Verified email at wakehealth.edu
Cited by 3148

Role of mesenchymal stem cells in regenerative medicine: application to bone and cartilage repair

F Granero-Molto, JA Weis, L Longobardi… - Expert opinion on …, 2008 - Taylor & Francis
Background: Mesenchymal stem cells (MSC) are multipotent cells with the ability to
differentiate into mesenchyme-derived cells including osteoblasts and chondrocytes …

Clinically relevant modeling of tumor growth and treatment response

TE Yankeelov, N Atuegwu, D Hormuth… - Science translational …, 2013 - science.org
Current mathematical models of tumor growth are limited in their clinical application
because they require input data that are nearly impossible to obtain with sufficient spatial …

Regenerative effects of transplanted mesenchymal stem cells in fracture healing

F Granero-Moltó, JA Weis, MI Miga, B Landis… - Stem …, 2009 - academic.oup.com
Mesenchymal stem cells (MSC) have a therapeutic potential in patients with fractures to
reduce the time of healing and treat nonunions. The use of MSC to treat fractures is attractive …

Multi-scale modeling in clinical oncology: opportunities and barriers to success

TE Yankeelov, G An, O Saut, EG Luebeck… - Annals of biomedical …, 2016 - Springer
Hierarchical processes spanning several orders of magnitude of both space and time
underlie nearly all cancers. Multi-scale statistical, mathematical, and computational …

TGF-β signaling is essential for joint morphogenesis

A Spagnoli, L O'Rear, RL Chandler… - The Journal of cell …, 2007 - rupress.org
Despite its clinical significance, joint morphogenesis is still an obscure process. In this study,
we determine the role of transforming growth factor β (TGF-β) signaling in mice lacking the …

Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression

VG Weis, JF Sousa, BJ LaFleur, KT Nam, JA Weis… - Gut, 2013 - gut.bmj.com
Objectives Spasmolytic polypeptide-expressing metaplasia (SPEM) develops as a
preneoplastic lesion in the stomachs of mice and humans after parietal cell loss. To identify …

Predicting the response of breast cancer to neoadjuvant therapy using a mechanically coupled reaction–diffusion model

JA Weis, MI Miga, LR Arlinghaus, X Li, V Abramson… - Cancer research, 2015 - AACR
Although there are considerable data on the use of mathematical modeling to describe
tumor growth and response to therapy, previous approaches are often not of the form that …

Mesenchymal Stem Cells Expressing Insulin-like Growth Factor-I (MSCIGF) Promote Fracture Healing and Restore New Bone Formation in Irs1 Knockout Mice: Analyses of MSC …

F Granero-Moltó, TJ Myers, JA Weis, L Longobardi… - Stem Cells, 2011 - academic.oup.com
Failures of fracture repair (nonunions) occur in 10% of all fractures. The use of mesenchymal
stem cells (MSC) in tissue regeneration appears to be rationale, safe, and feasible. The …

Near real-time computer assisted surgery for brain shift correction using biomechanical models

K Sun, TS Pheiffer, AL Simpson, JA Weis… - IEEE journal of …, 2014 - ieeexplore.ieee.org
Conventional image-guided neurosurgery relies on preoperative images to provide surgical
navigational information and visualization. However, these images are no longer accurate …

A mechanically coupled reaction–diffusion model that incorporates intra-tumoural heterogeneity to predict in vivo glioma growth

DA Hormuth, JA Weis, SL Barnes… - Journal of The …, 2017 - royalsocietypublishing.org
While gliomas have been extensively modelled with a reaction–diffusion (RD) type equation
it is most likely an oversimplification. In this study, three mathematical models of glioma …