The rapid evolution of drug discovery science, fuelled by combinatorial librarybased
synthesis programmes, has led to increased pressure on the drug safety evaluation process …

The composition and activity of the gut microbiota codevelop with the host from birth and is
subject to a complex interplay that depends on the host genome, nutrition, and life-style. The …

The later that a molecule or molecular class is lost from the drug development pipeline, the
higher the financial cost. Minimizing attrition is therefore one of the most important aims of a …

Metabolic profiling, metabolomic and metabonomic studies mainly involve the
multicomponent analysis of biological fluids, tissue and cell extracts using NMR …

Organisms often respond in complex and unpredictable ways to stimuli that cause disease
or injury. By measuring and mathematically modelling changes in the levels of products of …

The characteristics of the OPLS method have been investigated for the purpose of
discriminant analysis (OPLS‐DA). We demonstrate how class‐orthogonal variation can be …

To apply genomic knowledge effectively in drug discovery, mechanistic connectivities
between genetic variation and disease processes need to be established via systems …

Although a wide range of risk factors for coronary heart disease have been identified from
population studies, these measures, singly or in combination, are insufficiently powerful to …

There is a clear case for drug treatments to be selected according to the characteristics of an
individual patient, in order to improve efficacy and reduce the number and severity of …

The human gut harbors more than 100 trillion microbial cells, which have an essential role in
human metabolic regulation via their symbiotic interactions with the host. Altered gut …