About 20% of all human cancers are caused by chronic infection or chronic inflammatory
states. Recently, a new hypothesis has been proposed for prostate carcinogenesis. It …

Phospholipase A 2 (PLA 2) belongs to a family of enzymes that catalyze the cleavage of fatty
acids from the sn-2 position of phospholipids. There are more than 19 different isoforms of …

“Molecular farming” in plants with significant advantages in cost and safety is touted as a
promising platform for the production of complex pharmaceutical proteins. While whole-plant …

Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association …

The vast majority of coding variants are rare, and assessment of the contribution of rare
variants to complex traits is hampered by low statistical power and limited functional data …

Background Bronchial hyperresponsiveness, a risk factor for asthma, consists of a
heightened bronchoconstrictor response to a variety of stimuli. The condition has a heritable …

Prostate cancer is the most prevalent noncutaneous cancer in males in developed regions,
with African American men having among the highest worldwide incidence and mortality …

Chronic low-grade adipose tissue and liver inflammation is a major cause of systemic insulin
resistance and is a key component of the low degree of insulin sensitivity that exists in …

Despite its high prevalence, very little is known regarding genetic predisposition to prostate
cancer. A genome-wide scan performed in 66 high-risk prostate cancer families has …

Background Family history is a significant risk factor for prostate cancer, although the
molecular basis for this association is poorly understood. Linkage studies have implicated …