Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis
MV Machado, GA Michelotti, T de Almeida Pereira… - Gut, 2015 - gut.bmj.com
Objective Caspase-2 is an initiator caspase involved in multiple apoptotic pathways,
particularly in response to specific intracellular stressors (eg, DNA damage, ER stress). We …
particularly in response to specific intracellular stressors (eg, DNA damage, ER stress). We …
[PDF][PDF] A biotin switch-based proteomics approach identifies 14-3-3ζ as a target of Sirt1 in the metabolic regulation of caspase-2
JL Andersen, JW Thompson, KR Lindblom… - Molecular cell, 2011 - cell.com
While lysine acetylation in the nucleus is well characterized, comparatively little is known
about its significance in cytoplasmic signaling. Here we show that inhibition of the Sirt1 …
about its significance in cytoplasmic signaling. Here we show that inhibition of the Sirt1 …
[HTML][HTML] Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis
ES Johnson, KR Lindblom, A Robeson… - Journal of Biological …, 2013 - ASBMB
The accumulation of long-chain fatty acids (LCFAs) in non-adipose tissues results in lipid-
induced cytotoxicity (or lipoapoptosis). Lipoapoptosis has been proposed to play an …
induced cytotoxicity (or lipoapoptosis). Lipoapoptosis has been proposed to play an …
Dimer‐specific immunoprecipitation of active caspase‐2 identifies TRAF proteins as novel activators
AC Robeson, KR Lindblom, J Wojton… - The EMBO …, 2018 - embopress.org
Caspase‐2 has been shown to initiate apoptotic cell death in response to specific
intracellular stressors such as DNA damage. However, the molecular mechanisms …
intracellular stressors such as DNA damage. However, the molecular mechanisms …