Fllowing the identification of the hepatitis C virus (HCV) in 1989 (l), there was considerable
uncertainty about criteria for diagnosis of the liver disorder which was then known as …

A mutated cyclin-dependent kinase 4 (CDK4) was identified as a tumor-specific antigen
recognized by HLA-A2. 1-restricted autologous cytolytic T lymphocytes (CTLs) in a human …

Chronic intestinal inflammation induced by 2, 4, 6,–trinitrobenzene sulfonic acid (TNBS) is
characterized by a transmural granulomatous colitis that mimics some characteristics of …

Transforming growth factor-β1 (TGF-β1) is a powerful stimulus for collagen formation in vitro.
To determine the in vivo effects of TGF-β1 on liver fibrogenesis, we generated transgenic …

Hyporesponsiveness to a universe of bacterial and dietary antigens from the gut lumen is a
hallmark of the intestinal immune system. Since hyperresponsiveness against these …

Antibodies to tumor necrosis factor (TNF)‐α have been recently proposed as effective
treatment for patients with Crohn's disease. Here, we analyze the functional role of TNF‐α in …

We analyzed the molecular mechanisms by which IL-12 and IL-18 induce transcriptional
activity of the IFN-γ promoter in primary human CD4+ T cells. In transfection experiments, we …

Fat storing cells (FSCs) in the liver represent the main site of vitamin A deposition in the
body. These cells are considered to play an important role during scar formation and …

Interleukin 6 (IL-6) is considered an important mediator of acute inflammatory responses.
Moreover, IL-6 functions as a differentiation and growth factor of hematopoietic precursor …