[HTML][HTML] Detection of gene fusions using targeted next-generation sequencing: a comparative evaluation
C Heydt, CB Wölwer, O Velazquez Camacho… - BMC medical …, 2021 - Springer
Background Gene fusions represent promising targets for cancer therapy in lung cancer.
Reliable detection of multiple gene fusions is therefore essential. Methods Five …
Reliable detection of multiple gene fusions is therefore essential. Methods Five …
[HTML][HTML] Diffuse sclerosing variant of papillary thyroid carcinoma: lack of BRAF mutation but occurrence of RET/PTC rearrangements
SY Sheu, S Schwertheim, K Worm, F Grabellus… - Modern Pathology, 2007 - Elsevier
Diffuse sclerosing variant of papillary thyroid carcinoma (PTC) is a rare tumour with a
characteristic morphology as well as a strong preponderance for younger female patients …
characteristic morphology as well as a strong preponderance for younger female patients …
Exercise during pregnancy mitigates Alzheimer‐like pathology in mouse offspring
A Herring, A Donath, M Yarmolenko, E Uslar… - The FASEB …, 2012 - Wiley Online Library
Physical activity protects brain function in healthy individuals and those with Alzheimer's
disease (AD). Evidence for beneficial effects of parental exercise on the health status of their …
disease (AD). Evidence for beneficial effects of parental exercise on the health status of their …
[HTML][HTML] Different micro-RNA expression profiles distinguish subtypes of neuroendocrine tumors of the lung: results of a profiling study
FD Mairinger, S Ting, R Werner, RFH Walter, T Hager… - Modern Pathology, 2014 - Elsevier
MicroRNAs (miRNAs) are a class of small (∼ 22 nucleotides), non-coding, highly conserved
single-stranded RNAs with posttranscriptional regulatory features, including the regulation of …
single-stranded RNAs with posttranscriptional regulatory features, including the regulation of …
Impact of RAS mutation subtype on clinical outcome—a cross-entity comparison of patients with advanced non-small cell lung cancer and colorectal cancer
Mutated RAS onco-proteins are key drivers across many cancers. The distribution of somatic
RAS mutations varies between cancer entities. Retrospective analyses have associated …
RAS mutations varies between cancer entities. Retrospective analyses have associated …
[HTML][HTML] High prevalence of concomitant oncogene mutations in prospectively identified patients with ROS1-positive metastatic lung cancer
M Wiesweg, WEE Eberhardt, H Reis, S Ting… - Journal of Thoracic …, 2017 - Elsevier
Objectives Chromosomal rearrangements involving ROS1 define a rare entity of lung
adenocarcinomas with exquisite sensitivity to molecularly targeted therapy. We report …
adenocarcinomas with exquisite sensitivity to molecularly targeted therapy. We report …
[HTML][HTML] Sorafenib inhibits intracellular signaling pathways and induces cell cycle arrest and cell death in thyroid carcinoma cells irrespective of histological origin or …
M Broecker-Preuss, S Müller, M Britten, K Worm… - BMC cancer, 2015 - Springer
Background Patients with dedifferentiated or anaplastic thyroid carcinomas currently lack
appropriate treatment options. Kinase inhibitors are among the most promising new agents …
appropriate treatment options. Kinase inhibitors are among the most promising new agents …
[HTML][HTML] Development of a highly sensitive and specific method for detection of circulating tumor cells harboring somatic mutations in non-small-cell lung cancer …
F Breitenbuecher, S Hoffarth, K Worm, D Cortes-Incio… - PLoS …, 2014 - journals.plos.org
Background Oncogenic mutations are powerful predictive biomarkers for molecularly
targeted cancer therapies. For mutation detection patients have to undergo invasive tumor …
targeted cancer therapies. For mutation detection patients have to undergo invasive tumor …
Curcumin induces G2/M arrest, apoptosis, NF-κB inhibition, and expression of differentiation genes in thyroid carcinoma cells
S Schwertheim, F Wein, K Lennartz, K Worm… - Journal of Cancer …, 2017 - Springer
Purpose The therapy of unresectable advanced thyroid carcinomas shows unfavorable
outcome. Constitutive nuclear factor-κB (NF-κB) activation in thyroid carcinomas frequently …
outcome. Constitutive nuclear factor-κB (NF-κB) activation in thyroid carcinomas frequently …
KIT-dependent and KIT-independent genomic heterogeneity of resistance in gastrointestinal stromal tumors—TORC1/2 inhibition as salvage strategy
T Mühlenberg, J Ketzer, MC Heinrich… - Molecular cancer …, 2019 - AACR
Sporadic gastrointestinal stromal tumors (GIST), characterized by activating mutations of KIT
or PDGFRA, favorably respond to KIT inhibitory treatment but eventually become resistant …
or PDGFRA, favorably respond to KIT inhibitory treatment but eventually become resistant …