INTRODUCTION Microglia, as the resident myeloid cells of the central nervous system, play
an important role in life-long brain maintenance and in pathology. Microglia are derived from …

The mammalian liver consists of hexagon-shaped lobules that are radially polarized by
blood flow and morphogens,,,. Key liver genes have been shown to be differentially …

Lung development and function arises from the interactions between diverse cell types and
lineages. Using single-cell RNA sequencing (RNA-seq), we characterize the cellular …

The liver carries a remarkable ability to regenerate rapidly after acute zonal damage. Single-
cell approaches are necessary to study this process, given the spatial heterogeneity of liver …

The intestinal epithelium is a highly structured tissue composed of repeating crypt-villus
units. Enterocytes perform the diverse tasks of absorbing a wide range of nutrients while …

Spatially resolved single-cell RNA sequencing (scRNAseq) is a powerful approach for
inferring connections between a cell's identity and its position in a tissue. We recently …

Bursts of nascent mRNA have been shown to lead to substantial cell-cell variation in
unicellular organisms, facilitating diverse responses to environmental challenges. It is …

Summary mRNA is thought to predominantly reside in the cytoplasm, where it is translated
and eventually degraded. Although nuclear retention of mRNA has a regulatory potential, it …

Multiple myeloma, a plasma cell malignancy, is the second most common blood cancer.
Despite extensive research, disease heterogeneity is poorly characterized, hampering …

The intestinal epithelium is a structured organ composed of crypts harboring Lgr5+ stem
cells, and villi harboring differentiated cells. Spatial transcriptomics have demonstrated …