Nabumetone is a nonsteroidal anti-inflammatory prodrug, which exerts its pharmacological
effects via the metabolite 6-methoxy-2-naphthylacetic acid (6-MNA). Nabumetone itself is …

Background & Aims: There is no medical treatment of proven benefit for primary sclerosing
cholangitis. This study aimed at studying the effect of a higher dose of ursodeoxycholic acid …

OBJECTIVES Proton pump inhibitors reduce ulcer recurrence in non-steroidal anti-
inflammatory drug (NSAID) users, but their impact in at-risk ulcer-free patients using the …

Objective Bile acids may play a role in the pathogenesis of IBS. We investigated the
potential effects of bile acids entering the colon and its role in the symptom pattern in IBS …

Objective. Patients with inflammatory bowel disease (IBD) often have low iron stores or
anaemia. There is controversy about whether iron should be supplemented orally or …

Ileocaecal resection for Crohn's disease is commonly performed. The severity of endoscopic
lesions in the anastomotic area one year postoperatively is considered to reflect the …

Abstract Background and Aims: Anti-tumour necrosis factor [TNF] therapy is used in patients
with ulcerative colitis [UC], but not all patients respond to treatment. Antimicrobial peptides …

Abstract Background: Recurrent Clostridium difficile infection (CDI) is a significant problem
due to its increased incidence and severity. Failure rates for standard antibiotic therapies are …

OBJECTIVE Overweight has recently been shown to accelerate small bowel transit. The role
of gut transit and body weight in idiopathic bile acid malabsorption (IBAM) is unclear. We …

Background Targeted therapy, using biomarkers to assess disease activity in ulcerative
colitis (UC), has been proposed. Objective The objective of this study was to evaluate …