User profiles for "author:Klaus Pantel"
Klaus PantelProfessor der Medizin Verified email at uke.de Cited by 88973 |
Cell-free nucleic acids as biomarkers in cancer patients
DNA, mRNA and microRNA are released and circulate in the blood of cancer patients.
Changes in the levels of circulating nucleic acids have been associated with tumour burden …
Changes in the levels of circulating nucleic acids have been associated with tumour burden …
Dissecting the metastatic cascade
K Pantel, RH Brakenhoff - Nature reviews cancer, 2004 - nature.com
Despite recent progress in gene-expression profiling studies, the biology underlying the
various patterns of metastasis that are observed in different tumour types remains unclear …
various patterns of metastasis that are observed in different tumour types remains unclear …
Detection, clinical relevance and specific biological properties of disseminating tumour cells
Most cancer deaths are caused by haematogenous metastatic spread and subsequent
growth of tumour cells at distant organs. Disseminating tumour cells present in the …
growth of tumour cells at distant organs. Disseminating tumour cells present in the …
Tumour exosome integrins determine organotropic metastasis
A Hoshino, B Costa-Silva, TL Shen, G Rodrigues… - Nature, 2015 - nature.com
Abstract Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has
remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from …
remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from …
[HTML][HTML] A pooled analysis of bone marrow micrometastasis in breast cancer
S Braun, FD Vogl, B Naume, W Janni… - New England journal …, 2005 - Mass Medical Soc
Background We assessed the prognostic significance of the presence of micrometastasis in
the bone marrow at the time of diagnosis of breast cancer by means of a pooled analysis …
the bone marrow at the time of diagnosis of breast cancer by means of a pooled analysis …
Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the CellSearch system
S Riethdorf, H Fritsche, V Müller, T Rau… - Clinical cancer …, 2007 - AACR
Abstract Purpose: The CellSearch system (Veridex, Warren, NJ) is designed to enrich and
enumerate circulating tumor cells (CTCs) from peripheral blood. Here, we validated the …
enumerate circulating tumor cells (CTCs) from peripheral blood. Here, we validated the …
In vitro differentiation of endothelial cells from AC133-positive progenitor cells
UM Gehling, S Ergün, U Schumacher… - Blood, The Journal …, 2000 - ashpublications.org
Recent findings support the hypothesis that the CD34+-cell population in bone marrow and
peripheral blood contains hematopoietic and endothelial progenitor and stem cells. In this …
peripheral blood contains hematopoietic and endothelial progenitor and stem cells. In this …
Clinical applications of circulating tumor cells and circulating tumor DNA as liquid biopsy
C Alix-Panabières, K Pantel - Cancer discovery, 2016 - AACR
Abstract “Liquid biopsy” focusing on the analysis of circulating tumor cells (CTC) and
circulating cell-free tumor DNA (ctDNA) in the blood of patients with cancer has received …
circulating cell-free tumor DNA (ctDNA) in the blood of patients with cancer has received …
PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis
VS LeBleu, JT O'Connell, KN Gonzalez Herrera… - Nature cell …, 2014 - nature.com
Cancer cells can divert metabolites into anabolic pathways to support their rapid
proliferation and to accumulate the cellular building blocks required for tumour growth …
proliferation and to accumulate the cellular building blocks required for tumour growth …
Challenges in circulating tumour cell research
C Alix-Panabières, K Pantel - Nature Reviews Cancer, 2014 - nature.com
During the past ten years, circulating tumour cells (CTCs) have received enormous attention
as new biomarkers and the subject of basic research. Although CTCs are already used in …
as new biomarkers and the subject of basic research. Although CTCs are already used in …