User profiles for "author:Klaus Pantel"

Klaus Pantel

Professor der Medizin
Verified email at uke.de
Cited by 88973

Cell-free nucleic acids as biomarkers in cancer patients

H Schwarzenbach, DSB Hoon, K Pantel - Nature Reviews Cancer, 2011 - nature.com
DNA, mRNA and microRNA are released and circulate in the blood of cancer patients.
Changes in the levels of circulating nucleic acids have been associated with tumour burden …

Dissecting the metastatic cascade

K Pantel, RH Brakenhoff - Nature reviews cancer, 2004 - nature.com
Despite recent progress in gene-expression profiling studies, the biology underlying the
various patterns of metastasis that are observed in different tumour types remains unclear …

Detection, clinical relevance and specific biological properties of disseminating tumour cells

K Pantel, RH Brakenhoff, B Brandt - Nature Reviews Cancer, 2008 - nature.com
Most cancer deaths are caused by haematogenous metastatic spread and subsequent
growth of tumour cells at distant organs. Disseminating tumour cells present in the …

Tumour exosome integrins determine organotropic metastasis

A Hoshino, B Costa-Silva, TL Shen, G Rodrigues… - Nature, 2015 - nature.com
Abstract Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has
remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from …

[HTML][HTML] A pooled analysis of bone marrow micrometastasis in breast cancer

S Braun, FD Vogl, B Naume, W Janni… - New England journal …, 2005 - Mass Medical Soc
Background We assessed the prognostic significance of the presence of micrometastasis in
the bone marrow at the time of diagnosis of breast cancer by means of a pooled analysis …

Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the CellSearch system

S Riethdorf, H Fritsche, V Müller, T Rau… - Clinical cancer …, 2007 - AACR
Abstract Purpose: The CellSearch system (Veridex, Warren, NJ) is designed to enrich and
enumerate circulating tumor cells (CTCs) from peripheral blood. Here, we validated the …

In vitro differentiation of endothelial cells from AC133-positive progenitor cells

UM Gehling, S Ergün, U Schumacher… - Blood, The Journal …, 2000 - ashpublications.org
Recent findings support the hypothesis that the CD34+-cell population in bone marrow and
peripheral blood contains hematopoietic and endothelial progenitor and stem cells. In this …

Clinical applications of circulating tumor cells and circulating tumor DNA as liquid biopsy

C Alix-Panabières, K Pantel - Cancer discovery, 2016 - AACR
Abstract “Liquid biopsy” focusing on the analysis of circulating tumor cells (CTC) and
circulating cell-free tumor DNA (ctDNA) in the blood of patients with cancer has received …

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

VS LeBleu, JT O'Connell, KN Gonzalez Herrera… - Nature cell …, 2014 - nature.com
Cancer cells can divert metabolites into anabolic pathways to support their rapid
proliferation and to accumulate the cellular building blocks required for tumour growth …

Challenges in circulating tumour cell research

C Alix-Panabières, K Pantel - Nature Reviews Cancer, 2014 - nature.com
During the past ten years, circulating tumour cells (CTCs) have received enormous attention
as new biomarkers and the subject of basic research. Although CTCs are already used in …