[HTML][HTML] Computational methods for the pharmacogenetic interpretation of next generation sequencing data
Y Zhou, K Fujikura, S Mkrtchian… - Frontiers in …, 2018 - frontiersin.org
Up to half of all patients do not respond to pharmacological treatment as intended. A
substantial fraction of these inter-individual differences is due to heritable factors and a …
substantial fraction of these inter-individual differences is due to heritable factors and a …
[HTML][HTML] NANOGrav signal from a dark conformal phase transition
K Fujikura, S Girmohanta, Y Nakai, M Suzuki - Physics Letters B, 2023 - Elsevier
We explore the possibility that a confining first-order phase transition of a nearly-conformal
dark sector generates the reported NANOGrav signal of a stochastic gravitational wave …
dark sector generates the reported NANOGrav signal of a stochastic gravitational wave …
Multiregion whole-exome sequencing of intraductal papillary mucinous neoplasms reveals frequent somatic KLF4 mutations predominantly in low-grade regions
K Fujikura, W Hosoda, M Felsenstein, Q Song… - Gut, 2021 - gut.bmj.com
Objective Intraductal papillary mucinous neoplasms (IPMNs) are non-invasive precursor
lesions that can progress to invasive pancreatic cancer and are classified as low-grade or …
lesions that can progress to invasive pancreatic cancer and are classified as low-grade or …
Genetic variation in the human cytochrome P450 supergene family
K Fujikura, M Ingelman-Sundberg… - Pharmacogenetics and …, 2015 - journals.lww.com
Objectives Single nucleotide variations (SNVs) in the cytochrome P450 (CYP) gene family
are a primary cause of interindividual differences in therapeutic effects and adverse …
are a primary cause of interindividual differences in therapeutic effects and adverse …
[HTML][HTML] Dichotomy in intrahepatic cholangiocarcinomas based on histologic similarities to hilar cholangiocarcinomas
M Akita, K Fujikura, T Ajiki, T Fukumoto, K Otani… - Modern Pathology, 2017 - Elsevier
Intrahepatic cholangiocarcinomas were classified into two types based on their microscopic
appearance. Tumors with histologic similarities to hilar cholangiocarcinomas (predominantly …
appearance. Tumors with histologic similarities to hilar cholangiocarcinomas (predominantly …
Pattern of invasion in human pancreatic cancer organoids is associated with loss of SMAD4 and clinical outcome
W Huang, B Navarro-Serer, YJ Jeong, P Chianchiano… - Cancer research, 2020 - AACR
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy characterized by
extensive local invasion and systemic spread. In this study, we employed a three …
extensive local invasion and systemic spread. In this study, we employed a three …
Comparative clinicopathological study of biliary intraductal papillary neoplasms and papillary cholangiocarcinomas
K Fujikura, T Fukumoto, T Ajiki, K Otani… - …, 2016 - Wiley Online Library
Aims The aim of this study was to achieve a better definition of intraductal papillary
neoplasms of the bile duct (IPNB s). Methods and results Biliary tumours that showed …
neoplasms of the bile duct (IPNB s). Methods and results Biliary tumours that showed …
A more attractive scheme for radion stabilization and supercooled phase transition
A bstract We propose a new radion stabilization mechanism in the Randall-Sundrum
spacetime, introducing a bulk SU (NH) gauge field which confines at a TeV scale. It turns out …
spacetime, introducing a bulk SU (NH) gauge field which confines at a TeV scale. It turns out …
Uncovering the spatial landscape of molecular interactions within the tumor microenvironment through latent spaces
Recent advances in spatial transcriptomics (STs) enable gene expression measurements
from a tissue sample while retaining its spatial context. This technology enables …
from a tissue sample while retaining its spatial context. This technology enables …
Recurrent mutations in APC and CTNNB1 and activated Wnt/β-catenin signaling in intraductal papillary neoplasms of the bile duct: a whole exome sequencing study
K Fujikura, M Akita, T Ajiki, T Fukumoto… - The American Journal …, 2018 - journals.lww.com
This study aimed to elucidate the genetic landscape of biliary papillary neoplasms. Of 28
cases examined, 7 underwent whole exome sequencing, while the remaining 21 were used …
cases examined, 7 underwent whole exome sequencing, while the remaining 21 were used …