Abstract Knowledge concerning the pathogenesis of many bacterial diseases in fish is
limited, especially in those diseases that occur in warmwater species. This limited …

The vast majority of cancers arise as a consequence of exposure to environmental agents
that are toxic or mutagenic. In response to this, all higher organisms have evolved complex …

Xenobiotic metabolism and detoxification is regulated by receptors (eg, PXR, CAR) whose
characterization has contributed significantly to our understanding of drug responses in …

Resveratrol is a cancer preventative agent that is found in red wine. Piceatannol is a closely
related stilbene that has antileukaemic activity and is also a tyrosine kinase inhibitor …

2-(4-Aminophenyl) benzothiazoles display potent and selective antitumor activity against
inter alia breast, ovarian, colon, and renal cell lines, but their mechanism of action, though …

Background—Arylamine N-acetyltransferases in humans (NAT1 and NAT2) catalyse the
acetylation of arylamines including food derived heterocyclic arylamine carcinogens. Other …

This chapter introduces xenobiotic metabolism (in this chapter, the terms “xenobiotic
metabolism” and “xenobiotic-metabolizing enzyme” will be used in preference to “drug …

Acetyl Coenzyme A-dependent N-, O-and N, O-acetylation of aromatic amines and
hydrazines by arylamine N-acetyltransferases is well characterised. Here, we describe …

The observation that oncogenes are frequently activated in human tumours raises the
question of whether these genes are involved in chemical carcinogenesis. H-ras activation …

The pharmacokinetic and safety assessment of drug candidates is becoming increasingly
dependent upon in vitro models of hepatic metabolism and toxicity. Predominant among …