Ursodeoxycholic acid, a dihydroxyl bile acid normally present in human beings in minimal
amounts, becomes incorporated into the bile salt pool when taken orally. In cholestasis, bile …

Obliterative lesions in portal veins (PVs) and hepatic veins (HVs) of all sizes are known to
occur in cirrhotic livers. PV lesions have generally been attributed to thrombosis, but the …

Background To determine whether the orally active iron chelator deferiprone (1, 2-dimethyl-
3-hydroxypyridin-4-one) is efficacious in the treatment of iron overload in patients with …

The systemic cardiovascular complications of cirrhosis include generalized vasodilatation
manifested clinically as hypotension, decreased systemic vascular resistance, increased …

Hyponatremia in advanced cirrhosis and ascites or congestive heart failure (CHF) is the
result of an inappropriate increase in vasopressin secretion, which acts through activation of …

The clinical presentation and outcome of 32 children with primary sclerosing cholangitis
(PSC) are reviewed, the largest North American series. The majority of patients were …

Abstract Background and Methods. We describe a new form of hepatitis, occurring in 10
patients over a period of six years, characterized clinically by manifestations of severe …

Modifying the rate of absorption has been proposed as a therapeutic principle of specific
relevance to diabetes. To demonstrate clearly the metabolic benefits that might result from …

A 12-month prospective study was undertaken to determine prevalence and causes of
clinical and subclinical liver disease in 260 SLE patients and 100 controls, and to look for …

Early and accurate diagnosis and prognosis of patients with fulminant liver failure is of
critical importance for optimum management. We investigated the role of transjugular liver …