Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome
AJMH Verkerk, M Pieretti, JS Sutcliffe, YH Fu, DPA Kuhl… - Cell, 1991 - cell.com
Fragile X syndrome is the most frequent form of inherited mental retardation and is
associated with a fragile site at Xq27. 3. We identified human YAC clones that span fragile X …
associated with a fragile site at Xq27. 3. We identified human YAC clones that span fragile X …
β-catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis
W van Veelen, NH Le, W Helvensteijn, L Blonden… - Gut, 2011 - gut.bmj.com
Objective Deregulation of the Wnt signalling pathway by mutations in the Apc or β-catenin
genes underlies colorectal carcinogenesis. As a result, β-catenin stabilises, translocates to …
genes underlies colorectal carcinogenesis. As a result, β-catenin stabilises, translocates to …
Endothelial cell–specific FGD5 involvement in vascular pruning defines neovessel fate in mice
C Cheng, R Haasdijk, D Tempel, EHM van de Kamp… - Circulation, 2012 - Am Heart Assoc
Background—New vessel formation contributes to organ development during
embryogenesis and tissue repair in response to mechanical damage, inflammation, and …
embryogenesis and tissue repair in response to mechanical damage, inflammation, and …
Ets2 determines the inflammatory state of endothelial cells in advanced atherosclerotic lesions
C Cheng, D Tempel, WK Den Dekker… - Circulation …, 2011 - Am Heart Assoc
Rationale: Neovascularization is required for embryonic development and plays a central
role in diseases in adults. In atherosclerosis, the role of neovascularization remains to be …
role in diseases in adults. In atherosclerosis, the role of neovascularization remains to be …
DNA repair in cardiomyocytes is critical for maintaining cardiac function in mice
M de Boer, M te Lintel Hekkert, J Chang… - Aging cell, 2023 - Wiley Online Library
Heart failure has reached epidemic proportions in a progressively ageing population. The
molecular mechanisms underlying heart failure remain elusive, but evidence indicates that …
molecular mechanisms underlying heart failure remain elusive, but evidence indicates that …
[HTML][HTML] Cellular, mitochondrial and molecular alterations associate with early left ventricular diastolic dysfunction in a porcine model of diabetic metabolic …
The prevalence of diabetic metabolic derangement (DMetD) has increased dramatically
over the last decades. Although there is increasing evidence that DMetD is associated with …
over the last decades. Although there is increasing evidence that DMetD is associated with …
THSD1 preserves vascular integrity and protects against intraplaque haemorrhaging in ApoE−/− mice
RA Haasdijk, WK Den Dekker, C Cheng… - Cardiovascular …, 2016 - academic.oup.com
Aims Impairment of the endothelial barrier leads to microvascular breakdown in
cardiovascular disease and is involved in intraplaque haemorrhaging and the progression …
cardiovascular disease and is involved in intraplaque haemorrhaging and the progression …
Cgnl1, an endothelial junction complex protein, regulates GTPase mediated angiogenesis
I Chrifi, D Hermkens, MM Brandt… - Cardiovascular …, 2017 - academic.oup.com
Aims The formation of cell–cell and cell–extra cellular matrix (ECM) contacts by endothelial
cells (ECs) is crucial for the stability and integrity of a vascular network. We previously …
cells (ECs) is crucial for the stability and integrity of a vascular network. We previously …
PDGF-induced migration of vascular smooth muscle cells is inhibited by heme oxygenase-1 via VEGFR2 upregulation and subsequent assembly of inactive VEGFR2 …
C Cheng, RA Haasdijk, D Tempel… - … , and vascular biology, 2012 - Am Heart Assoc
Objective—In cardiovascular regulation, heme oxygenase-1 (HO-1) activity has been shown
to inhibit vascular smooth muscle cell (VSMC) proliferation by promoting cell cycle arrest at …
to inhibit vascular smooth muscle cell (VSMC) proliferation by promoting cell cycle arrest at …
Fiber FISH as a DNA mapping tool
AK Raap, RJ Florijn, LAJ Blonden, J Wiegant… - Methods, 1996 - Elsevier
Fluorescencein situhybridization (FISH) applied to metaphase chromosomes provides a
mapping resolution of 1 to 3 Mb. FISH applied to interphase nuclei has a resolution of 50 kb …
mapping resolution of 1 to 3 Mb. FISH applied to interphase nuclei has a resolution of 50 kb …