Objective Gastric cancer is a major gastrointestinal malignancy for which targeted therapies
are emerging as treatment options. This study sought to identify the most prevalent …

Background & Aims Almost all gastric cancers are adenocarcinomas, which have
considerable heterogeneity among patients. We sought to identify subtypes of gastric …

Birth weight within the normal range is associated with a variety of adult-onset diseases, but
the mechanisms behind these associations are poorly understood. Previous genome-wide …

Central corneal thickness (CCT) is a risk factor of glaucoma, the most common cause of
irreversible blindness worldwide. The identification of genetic determinants affecting CCT in …

Epigenetic alterations are fundamental hallmarks of cancer genomes. We surveyed the
landscape of DNA methylation alterations in gastric cancer by analyzing genome-wide CG …

Objective Gastric cancer (GC) is a deadly malignancy for which new therapeutic strategies
are needed. Three transcription factors, KLF5, GATA4 and GATA6, have been previously …

As one of the leading causes of visual impairment and blindness, myopia poses a significant
public health burden in Asia. The primary determinant of myopia is an elongated ocular axial …

Myopia is a complex genetic disorder and a common cause of visual impairment among
working age adults. Genome-wide association studies have identified susceptibility loci on …

Chromatin alterations are fundamental hallmarks of cancer. To study chromatin alterations in
primary gastric adenocarcinomas, we perform nanoscale chromatin immunoprecipitation …

Genetic alterations in kinases have been linked to multiple human pathologies. To explore
the landscape of kinase genetic variation in gastric cancer (GC), we used targeted, paired …