▪ Abstract Apoptosis of mature T lymphocytes preserves peripheral homeostasis and
tolerance by countering the profound changes in the number and types of T cells stimulated …

In December 2019, the outbreak of pneumonia caused by a novel coronavirus, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to a serious pandemic in China …

The death effector domain (DED) occurs in proteins that regulate programmed cell death.
Both pro-and anti-apoptotic proteins containing DEDs have been identified. For Fas and …

A key issue in mammalian immunology is how CD4+ CD25+ Foxp3+ regulatory T cells (Treg
cells) suppress immune responses. Here we show that Treg cells induced apoptosis of …

Autophagy is an evolutionarily conserved process by which cytoplasmic proteins and
organelles are catabolized,. During starvation, the protein TOR (target of rapamycin), a …

T-CELL receptor-induced apoptosis regulates immune responses and can result from
interactions between Fas (Apol/CD95) and Fas ligand (FasL) 1-12. Mutations in the genes …

A conserved domain in the extracellular region of the 60-and 80-kilodalton tumor necrosis
factor receptors (TNFRs) was identified that mediates specific ligand-independent assembly …

Apoptosis is a form of programmed cell death that is controlled by aspartate-specific cysteine
proteases called caspases. In the immune system, apoptosis counters the proliferation of …

Caspases are cysteine proteases that mediate programmed cell death in phylogenetically
diverse multicellular organisms. We report here two kindreds with autoimmune …

Mutations in the LRBA gene (encoding the lipopolysaccharide-responsive and beige-like
anchor protein) cause a syndrome of autoimmunity, lymphoproliferation, and humoral …