Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype
A Cougnoux, G Dalmasso, R Martinez, E Buc… - Gut, 2014 - gut.bmj.com
Background Escherichia coli strains harbouring the pks island (pks+ E. coli) are often seen
in human colorectal tumours and have a carcinogenic effect independent of inflammation in …
in human colorectal tumours and have a carcinogenic effect independent of inflammation in …
[PDF][PDF] Covalent docking of large libraries for the discovery of chemical probes
Chemical probes that form a covalent bond with a protein target often show enhanced
selectivity, potency, and utility for biological studies. Despite these advantages, protein …
selectivity, potency, and utility for biological studies. Despite these advantages, protein …
The Vat‐AIEC protease promotes crossing of the intestinal mucus layer by Crohn's disease‐associated Escherichia coli
L Gibold, E Garenaux, G Dalmasso… - Cellular …, 2016 - Wiley Online Library
The aetiology of Crohn's disease (CD) involves disorders in host genetic factors and
intestinal microbiota. Adherent‐invasive Escherichia coli (AIEC) are receiving increased …
intestinal microbiota. Adherent‐invasive Escherichia coli (AIEC) are receiving increased …
Small-molecule inhibitors prevent the genotoxic and protumoural effects induced by colibactin-producing bacteria
A Cougnoux, J Delmas, L Gibold, T Faïs, C Romagnoli… - Gut, 2016 - gut.bmj.com
Objective Colorectal cancers (CRCs) are frequently colonised by colibactin toxin-producing
Escherichia coli bacteria that induce DNA damage in host cells and exhibit protumoural …
Escherichia coli bacteria that induce DNA damage in host cells and exhibit protumoural …
Analysis of structure–function relationships in the colibactin-maturating enzyme ClbP
A Cougnoux, L Gibold, F Robin, D Dubois… - Journal of molecular …, 2012 - Elsevier
pks genomic island of Escherichia coli is involved in the synthesis of the non-ribosomal
peptide-type genotoxin colibactin, which has been suggesting as affecting the host immune …
peptide-type genotoxin colibactin, which has been suggesting as affecting the host immune …
[HTML][HTML] Metabolic adaptation of adherent-invasive Escherichia coli to exposure to bile salts
J Delmas, L Gibold, T Faïs, S Batista, M Leremboure… - Scientific Reports, 2019 - nature.com
The adherent-invasive Escherichia coli (AIEC), which colonize the ileal mucosa of Crohn's
disease patients, adhere to intestinal epithelial cells, invade them and exacerbate intestinal …
disease patients, adhere to intestinal epithelial cells, invade them and exacerbate intestinal …
In vitro efficiency of the piperacillin/tazobactam combination against inhibitor-resistant TEM- and complex mutant TEM-producing clinical strains of Escherichia coli
F Robin, M Krebs, J Delmas, L Gibold… - Journal of …, 2011 - academic.oup.com
Objectives We investigated the bacteriostatic and bactericidal activities of piperacillin/
tazobactam against 16 clinical Escherichia coli producing inhibitor-resistant TEM β …
tazobactam against 16 clinical Escherichia coli producing inhibitor-resistant TEM β …
Virulence factors and TEM-type β-lactamases produced by two isolates of an epidemic Klebsiella pneumoniae strain
F Robin, C Hennequin, M Gniadkowski… - Antimicrobial agents …, 2012 - Am Soc Microbiol
Two Klebsiella pneumoniae isolates of the same strain, identified in Poland, produced either
TEM-47 or TEM-68, which differed by the Arg275Leu substitution. They harbored a few …
TEM-47 or TEM-68, which differed by the Arg275Leu substitution. They harbored a few …
Résistances naturelles et acquises aux β-lactamines chez les entérobactéries: comment les identifier en pratique quotidienne?
F Robin, L Gibold, R Bonnet - Revue Francophone des laboratoires, 2012 - Elsevier
Résumé Les β-lactamines antibiotiques restent des molécules essentielles à la prise en
charge des infections dues aux entérobactéries. L'identification des mécanismes de …
charge des infections dues aux entérobactéries. L'identification des mécanismes de …
Noncovalent complexes of an inactive mutant of CTX-M-9 with the substrate piperacillin and the corresponding product
D Leyssene, J Delmas, F Robin… - Antimicrobial agents …, 2011 - Am Soc Microbiol
We determined the crystal structure of an inactive Ser70Gly mutant of CTX-M-9 in complex
with the bulky penicillin piperacillin at precovalent and posthydrolytic stages in the catalytic …
with the bulky penicillin piperacillin at precovalent and posthydrolytic stages in the catalytic …