Neddylation, a post-translational modification that adds an ubiquitin-like protein NEDD8 to
substrate proteins, modulates many important biological processes, including …

In light of the ongoing COVID-19 pandemic, the unexpected outbreak and worldwide spread
of monkeypox has gained global attention. As of June 22, 2022, there were 3340 confirmed …

Obesity is the most common nutritional disorder worldwide and is associated with
dyslipidemia and atherosclerotic cardiovascular disease. The hallmark of dyslipidemia in …

Background Cisplatin-based chemotherapy is frequently used to treat advanced gastric
cancer (GC). However, the resistance often occurs with the mechanisms being not well …

Objective In the tumour microenvironment, critical drivers of immune escape include the
oncogenic activity of the tumour cell-intrinsic osteopontin (OPN), the expression of …

In the recent outbreak of novel coronavirus infection worldwide, the risk of thrombosis and
bleeding should be concerned. We aimed to observe the dynamic changes of D-dimer …

Tumor-associated macrophages (TAMs) are a major component of the tumor
microenvironment and have been shown to contribute to tumor aggressiveness. However …

Background The propensity of the activated neutrophils to form extracellular traps (NETs) is
demonstrated in multiple inflammatory conditions. In this study, we investigated the roles of …

Epigenetic alterations are fundamental hallmarks of cancer genomes. We surveyed the
landscape of DNA methylation alterations in gastric cancer by analyzing genome-wide CG …

Intercellular cross-talk plays important roles in cancer progression and metastasis. Yet how
these cancer cells interact with each other is still largely unknown. Exosomes released by …