Lectin-mediated mucosal delivery of drugs and microparticles

MA Clark, BH Hirst, MA Jepson - Advanced drug delivery reviews, 2000 - Elsevier
Absorption of drugs and vaccines at mucosal surfaces may be enhanced by conjugation to
appropriate bioadhesins which bind to mucosal epithelia. Bioadhesins might also permit cell …

Exploiting M cells for drug and vaccine delivery

MA Clark, MA Jepson, BH Hirst - Advanced drug delivery reviews, 2001 - Elsevier
The specialised antigen sampling M cells represent an efficient portal for mucosal drug and
vaccine delivery. Delivery may be achieved using synthetic particulate delivery vehicles …

Keynote review: intestinal Peyer's patch M cells and oral vaccine targeting

DJ Brayden, MA Jepson, AW Baird - Drug discovery today, 2005 - Elsevier
Specialized M cells in the follicle-associated epithelium of intestinal Peyer's patches serve
as portals for diverse particulates. Following antigen handover to dome lymphocytes, a …

M-Cell Surface β1 Integrin Expression and Invasin-Mediated Targeting of Yersinia pseudotuberculosis to Mouse Peyer's Patch M Cells

MA Clark, BH Hirst, MA Jepson - Infection and immunity, 1998 - Am Soc Microbiol
Quantitative analysis of Yersinia pseudotuberculosis infection of murine gut loops revealed
that significantly more wild-type bacteria associated with Peyer's patch M cells than with …

Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators

J Hunter, MA Jepson, T Tsuruo, NL Simmons… - Journal of Biological …, 1993 - Elsevier
The functional expression of P-glycoprotein has been studied in confluent epithelial layers of
human Caco-2 cells, a polarized, highly differentiated cell line demonstrating an intestinal …

Differential expression of lectin-binding sites defines mouse intestinal M-cells.

MA Clark, MA Jepson, NL Simmons… - … of Histochemistry & …, 1993 - journals.sagepub.com
We investigated the binding of four lectins to the follicle-associated epithelium (FAE)
overlying fixed mouse small intestinal Peyer's patches to identify M-cell-specific surface …

Interspecies comparisons on the uptake and toxicity of silver and cerium dioxide nanoparticles

BK Gaiser, TF Fernandes, MA Jepson… - Environmental …, 2012 - Wiley Online Library
An increasing number and quantity of manufactured nanoparticles are entering the
environment as the diversity of their applications increases, and this will lead to the …

Preferential interaction of Salmonella typhimurium with mouse Peyer's patch M cells

MA Clark, MA Jepson, NL Simmons, BH Hirst - Research in microbiology, 1994 - Elsevier
We have used a mouse Peyer's patch gut loop model to investigate the role of the intestinal
membranous epithelial (M) cells in the pathogenesis of Salmonella typhimurium. These …

Norepinephrine increases the pathogenic potential of Campylobacter jejuni

TA Cogan, AO Thomas, LEN Rees, AH Taylor… - Gut, 2007 - gut.bmj.com
Background: Campylobacter jejuni can cause a spectrum of diseases in humans, ranging
from enteritis and diarrhoea to severe inflammation, profuse bloody diarrhoea and chronic …

[HTML][HTML] The role of M cells in Salmonella infection

MA Jepson, MA Clark - Microbes and infection, 2001 - Elsevier
Intestinal M cells, the specialised antigen-sampling cells of the mucosal immune system, are
exploited by Salmonella and other pathogens as a route of invasion. Salmonella entry into M …