User profiles for "author:M Exley"

Mark Exley

CSO & Honorary Research Associate (Prof.)
Verified email at mgb.org
Cited by 14794

[HTML][HTML] Interplay between the immune system and adipose tissue in obesity

MA Exley, L Hand, D O'Shea… - Journal of …, 2014 - joe.bioscientifica.com
Obesity is a major risk factor for metabolic disease, with white adipose tissue (WAT)
inflammation emerging as a key underlying pathology. Alongside its major role in energy …

[HTML][HTML] Novel approaches to exploiting invariant NKT cells in cancer immunotherapy

BJ Wolf, JE Choi, MA Exley - Frontiers in immunology, 2018 - frontiersin.org
iNKT cells are a subset of innate-like T cells that utilize an invariant TCR alpha chain
complexed with a limited repertoire of TCR beta chains to recognize specific lipid antigens …

[PDF][PDF] To be or not to be NKT: natural killer T cells in the liver

MA Exley, MJ Koziel - Hepatology, 2004 - Wiley Online Library
Much of the hepatology literature to date has focused on the adaptive, antigen‐specific
response mediated by classical T‐cell populations in both the protection and pathogenesis …

[HTML][HTML] Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis

…, S Fichtner-Feigl, Z Yang, M Exley… - The Journal of …, 2004 - Am Soc Clin Investig
While Crohn disease (CD) has been clearly identified as a Th1 inflammation, the
immunopathogenesis of its counterpart inflammatory bowel disease, ulcerative colitis (UC) …

[HTML][HTML] Multiple immuno-regulatory defects in type-1 diabetes

…, K Lin-Su, S Ten, M Sanz, M Exley… - The Journal of …, 2002 - Am Soc Clin Investig
Susceptibility to immune-mediated diabetes (IMD) in humans and NOD mice involves their
inherently defective T cell immunoregulatory abilities. We have followed natural killer (NK) T …

Erratum: Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes

…, SC Kent, KT Patton, T Orban, RA Jackson, M Exley… - Nature, 1999 - nature.com
Figure 3 of this Letter wrongly shows all cobalt sites as yellow filled circles, indicating that
they lie on the same c 0 level, whereas the two lower sites in the figure were intended to be …

[PDF][PDF] Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production

L Lynch, M Nowak, B Varghese, J Clark, AE Hogan… - Immunity, 2012 - cell.com
Invariant natural killer T (iNKT) cells are evolutionarily conserved innate T cells that
influence inflammatory responses. We have shown that iNKT cells, previously thought to be …

Requirements for CD1d Recognition by Human Invariant Vα24+ CD4CD8 T Cells

M Exley, J Garcia, SP Balk, S Porcelli - The Journal of experimental …, 1997 - rupress.org
A subset of human CD4− CD8− T cells that expresses an invariant Vα24-JαQ T cell receptor
(TCR)-α chain, paired predominantly with Vβ11, has been identified. A series of these Vα24 …

Loss of IFN-γ production by invariant NK T cells in advanced cancer

S Muhammad Ali Tahir, O Cheng… - The Journal of …, 2001 - journals.aai.org
Invariant NK T cells express certain NK cell receptors and an invariant TCRα chain specific
for the MHC class I-like CD1d protein. These invariant NK T cells can regulate diverse …

CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung

EES Nieuwenhuis, T Matsumoto, M Exley… - Nature medicine, 2002 - nature.com
CD1d-restricted T cells are implicated as key players in host defense against various
microbial infections. However, the mechanisms involved and the role they play, if any, at the …