In liver cirrhosis, abnormal persistent extrahepatic vasodilation leads to hyperdynamic
circulatory dysfunction which essentially contributes to portal hypertension. Since portal …

Prostatic α1‐adrenoceptors are known to be involved in the pathophysiology of lower
urinary tract symptoms (LUTS) in patients with benign prostate obstruction (BPO). It is widely …

Abstract In cirrhosis, increased RhoA/Rho‐kinase signaling and decreased nitric oxide (NO)
availability contribute to increased intrahepatic resistance and portal hypertension. Hepatic …

BACKGROUND & AIMS: Activation of hepatic stellate cells (HSC) and transdifferentiation to
myofibroblasts following liver injury is the main culprit for hepatic fibrosis. Myofibroblasts …

The bile acid pool with its individual bile acids (BA) is modulated in the enterohepatic
circulation by the liver as the primary site of synthesis, the motility of the gallbladder and of …

Background & Aims: Portal hypertension is associated with arterial hypotension and
vascular hypocontractility, which persists despite elevated plasma levels of vasoconstrictors …

Background: Alcohol is a common cause of hepatic liver injury with steatosis and fibrosis.
Cannabinoid receptors (CB) modulate steatosis, inflammation and fibrogenesis. To …

In cirrhosis, vascular hypocontractility leads to vasodilation and contributes to portal
hypertension. Impaired activation of contractile pathways contributes to vascular …

Background and aims: Portal hypertension in cirrhosis is mediated in part by increased
intrahepatic resistance, reflecting an increased sensitivity of the hepatic microvasculature to …

Background and purpose: Extrahepatic vasodilation and increased intrahepatic vascular
resistance represent attractive targets for the medical treatment of portal hypertension in liver …