Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

…, S Ben-Shabat, L Hanus, M Ligumsky… - Biochemical …, 1995 - Elsevier
In this study, we report the isolation from canine intestines of 2-arachidonyl glycerol (2-Ara-
Gl). Its structure was determined by mass spectrometry and by direct comparison with a …

Role of prostaglandins in ulcerative colitis: enhanced production during active disease and inhibition by sulfasalazine

P Sharon, M Ligumsky, D Rachmilewitz, U Zor - Gastroenterology, 1978 - Elsevier
Prostaglandin E 2 (PGE 2) level in rectal mucosa excised from 17 patients suffering from
ulcerative colitis was 2-fold higher than that found in rectal mucosa of 17 normal subjects …

Role of interleukin 1 in inflammatory bowel disease--enhanced production during active disease.

M Ligumsky, PL Simon, F Karmeli, D Rachmilewitz - Gut, 1990 - gut.bmj.com
Interleukin 1 is a polypeptide cytokine produced by various cell types and has been shown
to have a major role in inflammatory and immunological responses. In experimental colitis it …

A novel function of red wine polyphenols in humans: prevention of absorption of cytotoxic lipid peroxidation products

S Gorelik, M Ligumsky, R Kohen… - The FASEB Journal, 2008 - Wiley Online Library
Current evidence supports a contribution of polyphenols to the prevention of cardiovascular
disease, but their mechanisms of action are not understood. We investigated the impact of …

The stomach as a “bioreactor”: when red meat meets red wine

S Gorelik, M Ligumsky, R Kohen… - Journal of agricultural …, 2008 - ACS Publications
To determine the stomach bioreactor capability for food oxidation or antioxidation, rats were
fed red turkey meat cutlets (meal A) or red turkey meat cutlets and red wine concentrate …

Lipid peroxidation and coupled vitamin oxidation in simulated and human gastric fluid inhibited by dietary polyphenols: health implications

…, I Shaham, R Granit, M Ligumsky… - Journal of agricultural …, 2005 - ACS Publications
The Western diet contains large quantities of oxidized lipids, because a large proportion of
the food in the diet is consumed in a fried, heated, processed, or stored form. We …

Enhanced thromboxane A2 and prostacyclin production by cultured rectal mucosa in ulcerative colitis and its inhibition by steroids and sulfasalazine

M Ligumsky, F Karmeli, P Sharon, U Zor, F Cohen… - Gastroenterology, 1981 - Elsevier
Accumulation of 6-ketoprostaglandin F 1α and thromboxane B 2, the stable metabolites of
prostacyclin I 2 and thromboxane A 2 respectively, by cultured rectal mucosa obtained from …

Aspirin can inhibit gastric mucosal cyclo-oxygenase without causing lesions in rat

M Ligumsky, EM Golanska, DG Hansen… - Gastroenterology, 1983 - Elsevier
Dose-response relationships between aspirin-induced cyclo-oxygenase inhibition and
gastric mucosal injury were studied in rats. Oral or parenteral aspirin, 25 mg/kg, inhibited …

Antioxidants inhibit ethanol-induced gastric injury in the rat: role of manganese, glycine, and carotene

M Ligumsky, M Sestieri, E Okon… - Scandinavian journal of …, 1995 - Taylor & Francis
Background: Oxygen-derived radicals are implicated in the pathogenesis of tissue damage
and ulcerogenesis. This study aimed to examine the effect of manganese, glycine, and …

A Novel Treatment for Constipation-Predominant Irritable Bowel Syndrome Using Padma®Lax, a Tibetan Herbal Formula

…, R Davidson, H Shapiro, G Ginsberg, M Ligumsky - Digestion, 2002 - karger.com
Abstract Background and Aims: Padma Lax, a complex Tibetan herbal formula for
constipation was evaluated for safety and effectiveness in treating constipation-predominant …