The p53 tumor suppressor protein is a critical regulator of the cellular response to cancer-
initiating insults such as genotoxic stress. In this report, we demonstrate that microRNAs …

Multiple endocrine neoplasia type 1 (MEN1), among all syndromes, causes tumors in the
highest number of tissue types. Most of the tumors are hormone producing (eg, parathyroid …

In the context of pancreatic cancer, metastasis remains the most critical determinant of
resectability, and hence survival. The objective of this study was to determine whether …

Background: Intraductal papillary mucinous neoplasms (IPMNs) are non-invasive precursor
lesions of pancreatic cancer. Misexpression of microRNAs (miRNAs) is commonly observed …

Recent evidence suggests that blockade of aberrant Hedgehog signaling can be exploited
as a therapeutic strategy for pancreatic cancer. Our previous studies using the prototype …

Although activating mutations in RAS oncogenes are known to result in aberrant signaling
through multiple pathways, the role of microRNAs (miRNAs) in the Ras oncogenic program …

Background and aims: Pancreatic cancer is among the most dismal of human malignancies.
Current therapeutic strategies are virtually ineffective in controlling advanced, metastatic …

Purpose: Aberrant activation of the Notch signaling pathway is commonly observed in
human pancreatic cancer, although the mechanism (s) for this activation has not been …

MicroRNAs (miRNAs) are 21-24 nucleotide RNA molecules that regulate the translation and
stability of target messenger RNAs. Abnormal miRNA expression is a common feature of …

Purpose To establish whether NSC80467, a novel fused naphthquinone imidazolium, has a
similar spectrum of activity to the well-characterized “survivin suppressant” YM155 and to …