Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice

EF Verdu, P Bercik, M Verma-Gandhu, XX Huang… - Gut, 2006 - gut.bmj.com
Background and aim: Abdominal pain and discomfort are common symptoms in functional
disorders and are attributed to visceral hypersensitivity. These symptoms fluctuate over time …

T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity

…, C Johnston, M Verma-Gandhu… - Journal of …, 2009 - Soc Neuroscience
Partial peripheral nerve injury in adult rats results in neuropathic pain-like hypersensitivity,
while that in neonatal rats does not, a phenomenon also observed in humans. We therefore …

Critical role of MCP-1 in the pathogenesis of experimental colitis in the context of immune and enterochromaffin cells

…, EF Verdu, M Verma-Gandhu… - American Journal …, 2006 - journals.physiology.org
Mucosal changes in inflammatory bowel disease (IBD) are characterized by ulcerative
lesions accompanied by a prominent infiltrate of inflammatory cells including lymphocytes …

CD4+ T cell-mediated immunological control of enterochromaffin cell hyperplasia and 5-hydroxytryptamine production in enteric infection

…, J Steeds, Y Motomura, Y Deng, M Verma-Gandhu… - Gut, 2007 - gut.bmj.com
Background: Enterochromaffin (EC) cells are dispersed throughout the gastrointestinal (GI)
mucosa and are the main source of 5-hydroxytryptamine (5-HT) in the gut. 5-HT has been …

CD4+ T-cell modulation of visceral nociception in mice

M VermaGandhu, P Bercik, Y Motomura, EF Verdu… - Gastroenterology, 2006 - Elsevier
Background & Aims: Although inflammatory and immune cells are present in the gut in the
absence of pathology, their presence does not result in sensitization of sensory nerves …

Visceral pain perception is determined by the duration of colitis and associated neuropeptide expression in the mouse

M Verma-Gandhu, EF Verdu, P Bercik… - Gut, 2007 - gut.bmj.com
Background: Even though inflammation is a traditional tool for the induction of hyperalgesia
in many tissues, recent observations suggest that not all inflammatory processes produce …

Induction of a fibrogenic response in mouse colon by overexpression of monocyte chemoattractant protein 1

…, WI Khan, RT El-Sharkawy, M Verma-Gandhu… - Gut, 2006 - gut.bmj.com
Background and aims: Monocyte chemoattractant protein 1 (MCP-1) is increased
transmurally in inflammatory bowel disease (IBD). Although MCP-1 is considered to play an …

Lymphocyte-mediated regulation of β-endorphin in the myenteric plexus

M Verma-Gandhu, EF Verdu… - American Journal …, 2007 - journals.physiology.org
Lymphocytes are antinociceptive and can modulate visceral pain perception in mice.
Previously, we have shown that adoptive transfer of CD4+ T cells to severe combined …

Effect of fetuin, a TGFβ antagonist and pentoxifylline, a cytokine antagonist on hepatic stellate cell function and fibrotic parameters in fibrosis

M Verma-Gandhu, MR Peterson… - European journal of …, 2007 - Elsevier
We have previously shown that monocyte conditioned medium (MCM) from patients with
liver fibrosis stimulated proliferation of hepatic stellate cells (HSCs), the major cell involved …

Mechanisms underlying gut dysfunction in a murine model of chronic parasitic infection

…, RT El-Sharkawy, M Verma-Gandhu… - American Journal …, 2010 - journals.physiology.org
Irritable bowel syndrome (IBS) is common in countries where chronic parasitic infestations
are endemic. However, the relationship between parasitic infection and IBS is not clear. The …